The Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
The First School of Medicine, Wenzhou Medical University, Wenzhou, China.
Updates Surg. 2024 Aug;76(4):1195-1202. doi: 10.1007/s13304-023-01746-7. Epub 2024 Feb 2.
The clinical application of random flaps in wound repair has been a topic of discussion. Random flaps are prone to necrosis due to the lack of well-defined vascular blood supply during transfer surgery. Their clinical utility is restricted, financial and psychological burdens is imposed on patients due to this limitation. The survival of random skin flaps depends on factors such as ischemia-reperfusion injury, oxidative stress, local inflammatory response, and neovascularization. This review aims to provide an overview of the evidence supporting the use of random flaps in clinical practice. In addition, this review explores the impact of different medications on signaling pathways within the flap's local microcirculation and investigates the interconnections between these pathways.
随机皮瓣在创伤修复中的临床应用一直是讨论的话题。由于转移手术中缺乏明确的血管血液供应，随机皮瓣容易发生坏死。由于这种局限性，限制了它们的临床应用，给患者带来了经济和心理负担。随机皮瓣的存活取决于缺血再灌注损伤、氧化应激、局部炎症反应和新血管生成等因素。本文综述旨在提供支持随机皮瓣在临床实践中应用的证据概述。此外，本文还探讨了不同药物对皮瓣局部微循环中信号通路的影响，并研究了这些通路之间的相互联系。
