College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, China.
J Sci Food Agric. 2024 Jul;104(9):4989-5000. doi: 10.1002/jsfa.13353. Epub 2024 Feb 20.
Dietary intervention, including polyphenol consumption, is recognized as an effective strategy to prevent obesity. Although fermented jujube juice (FJJ) with lactic acid bacteria has been shown to be rich in polyphenols and have strong antioxidant properties, little is known about its anti-obesity properties.
Untargeted metabolomics was employed to identify and analyze the differential metabolites between FJJ and raw jujube juice. A total of 431 metabolites belonging to diverse classes and with various functional active ingredients were quantitatively identified. The animal experiments results showed that FJJ administration for 13 weeks significantly inhibited high-fat-diet-induced body and epididymal adipose weight gain, and improved the serum lipid parameters in obese mice. Additionally, DNA-sequencing results revealed that FJJ treatment increased Akkermansia abundance in the gut and changed the composition of fecal microbiota by decreasing the Firmicutes/Bacteroidota ratio and Helicobacter pylori abundance.
These findings suggest that FJJ contributes to regulating lipid accumulation and gut microbiota composition in high-fat-diet-induced obese mice, which helps to prevent obesity. Hence, FJJ has the potential to be a beneficial beverage for controlling obesity. © 2024 Society of Chemical Industry.
饮食干预，包括多酚类物质的摄入，被认为是预防肥胖的有效策略。虽然含有乳酸菌的发酵冬枣汁（FJJ）已被证明富含多酚类物质，具有很强的抗氧化性能，但对于其抗肥胖特性知之甚少。
本研究采用非靶向代谢组学方法，鉴定和分析了 FJJ 和原冬枣汁之间的差异代谢物。共定量鉴定了 431 种属于不同类别、具有各种功能活性成分的代谢物。动物实验结果表明，FJJ 给药 13 周可显著抑制高脂肪饮食诱导的肥胖小鼠体重和附睾脂肪重量增加，并改善肥胖小鼠的血清脂质参数。此外，DNA 测序结果表明，FJJ 处理可增加肠道内阿克曼氏菌的丰度，并通过降低厚壁菌门/拟杆菌门比值和幽门螺旋杆菌丰度来改变粪便微生物群的组成。
这些发现表明，FJJ 有助于调节高脂肪饮食诱导肥胖小鼠的脂质积累和肠道微生物群组成，有助于预防肥胖。因此，FJJ 有可能成为控制肥胖的有益饮料。 © 2024 化学工业协会。
