阻塞性睡眠呼吸暂停对生殖健康的影响：一项关于抗苗勒管激素水平的研究。
Implications of obstructive sleep apnea on reproductive health: a study on anti-Mullerian hormone levels.
机构信息
Department of Chest Disease, Faculty of Medicine, Van Yüzüncü Yıl University, Tuşba, Van, 65080, Turkey.
Department of Biochemistry, Faculty of Medicine, Van Yüzüncü Yıl University, Tuşba, Van, 65080, Turkey.
出版信息
Sleep Breath. 2024 Jun;28(3):1217-1222. doi: 10.1007/s11325-024-02998-2. Epub 2024 Feb 3.
PURPOSE
This study aimed to explore the association between anti-mullerian hormone (AMH) levels and obstructive sleep apnea (OSA) severity.
METHODS
A cross-sectional design was employed to evaluate AMH levels in 68 premenopausal women diagnosed with OSA at Van Yüzüncü Yıl University Faculty of Medicine. OSA severity was scored according to the 2018 AASM guidelines using a 16-channel Embla device. AMH levels were measured from blood samples using a commercially available kit.
RESULTS
The study found that AMH levels in OSA patients were significantly lower than those in the healthy control group. A statistically significant negative correlation between AMH and AHI levels was observed. When stratified by OSA severity, the lowest AMH levels were found in the severe OSA group.
CONCLUSION
OSA may have potential endocrine implications, especially concerning reproductive health. Decreased AMH levels in OSA patients could indicate future risks of infertility or early menopause.
目的
本研究旨在探讨抗缪勒管激素（AMH）水平与阻塞性睡眠呼吸暂停（OSA）严重程度之间的关系。
方法
采用横断面设计，评估了 68 名在凡大学医学院被诊断为 OSA 的绝经前妇女的 AMH 水平。根据 2018 年 AASM 指南，使用 16 通道 Embla 设备对 OSA 严重程度进行评分。使用市售试剂盒从血液样本中测量 AMH 水平。
结果
研究发现，OSA 患者的 AMH 水平明显低于健康对照组。观察到 AMH 与 AHI 水平之间存在显著的负相关。按 OSA 严重程度分层时，在重度 OSA 组中发现了最低的 AMH 水平。
结论
OSA 可能具有潜在的内分泌影响，特别是与生殖健康有关。OSA 患者的 AMH 水平降低可能表明未来不孕或早绝经的风险增加。
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