Celal Bayar University, Department of Neurology, Manisa 45000, Turkey.
Ege University Department of Clinical Biochemistry, Bornova, Izmir 35000, Turkey.
Clin Neurol Neurosurg. 2024 Feb;237:108136. doi: 10.1016/j.clineuro.2024.108136. Epub 2024 Jan 26.
Calcitonin gene-related peptide (CGRP) plays a dominant role in migraine. This prospective study was designed to investigate CGRP levels in patients with idiopathic intracranial hypertension (IIH) and compare the results of migraine patients and healthy controls (HC). As a second objective, CGRP levels obtained from IIH patients defining sustained headache after the resolution of papilledema were compared with those not defining post-IIH headache.
Thirty-six patients with IIH, 36 with episodic migraine (EM), 18 with chronic migraine (CM), and 36 HC were included in the study. CGRP levels were studied from blood samples obtained from the antecubital vein by using a commercial ELISA kit.
Serum CGRP levels of the patient groups were significantly higher than the HC (p < 0.001). As compared with controls, both CM (p Adj<0.001) and IIH (p Adj=0.039) had significantly increased levels of CGRP. Levels recorded from EM patients did not differ from the HC (p Adj=0.661). In 16 IIH patients, persistent headache was reported after the normalization of intracranial pressure (ICP). Twenty patients did not report post-IIH headaches. Comparison of serum CGRP levels of these two groups revealed significantly higher CGRP levels in patients with sustained headaches obtained from blood samples both at the initial and control visit (p Adj <0.001).
CGRP levels of the patient groups were higher than the HC. High levels recorded in patients with IIH indicates the role of CGRP in IIH related headache and even higher levels in patients with sustained headache after normalization of ICP strengthens this finding.
降钙素基因相关肽（CGRP）在偏头痛中起主导作用。本前瞻性研究旨在调查特发性颅内高压（IIH）患者的 CGRP 水平，并将结果与偏头痛患者和健康对照者（HC）进行比较。作为第二个目标，比较缓解视乳头水肿后持续头痛的 IIH 患者与不定义 IIH 后头痛的患者的 CGRP 水平。
研究纳入 36 例 IIH 患者、36 例发作性偏头痛（EM）患者、18 例慢性偏头痛（CM）患者和 36 例 HC。通过商业 ELISA 试剂盒从肘前静脉采集血样，研究 CGRP 水平。
患者组血清 CGRP 水平明显高于 HC（p<0.001）。与对照组相比，CM（pAdj<0.001）和 IIH（pAdj=0.039）患者的 CGRP 水平均显著升高。EM 患者的水平与 HC 无差异（pAdj=0.661）。在 16 例 IIH 患者中，颅内压（ICP）正常后仍报告持续性头痛。20 例患者未报告 IIH 后头痛。比较这两组患者的血清 CGRP 水平，发现持续性头痛患者的 CGRP 水平在初始和对照就诊时均显著升高（pAdj<0.001）。
患者组的 CGRP 水平高于 HC。IIH 患者记录的高水平表明 CGRP 在 IIH 相关头痛中的作用，甚至在 ICP 正常后持续头痛患者中更高的水平进一步证实了这一发现。
