School of Science, Monash University (Malaysia Campus), Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia.
School of Science, Monash University (Malaysia Campus), Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia.
Bioorg Chem. 2024 Mar;144:107150. doi: 10.1016/j.bioorg.2024.107150. Epub 2024 Jan 27.
Nucleobases serve as essential molecular frameworks present in both natural and synthetic compounds that exhibit notable antiviral activity. Through molecular modifications, novel nucleobase-containing drugs (NCDs) have been developed, exhibiting enhanced antiviral activity against a wide range of viruses, including the recently emerged SARS‑CoV‑2. This article provides a detailed examination of the significant advancements in NCDs from 2015 till current, encompassing various aspects concerning their mechanisms of action, pharmacology and antiviral properties. Additionally, the article discusses antiviral prodrugs relevant to the scope of this review. It fills in the knowledge gap by examining the structure-activity relationship and trend of NCDs as therapeutics against a diverse range of viral diseases, either as approved drugs, clinical candidates or as early-stage development prospects. Moreover, the article highlights on the status of this field of study and addresses the prevailing limitations encountered.
碱基是天然和合成化合物中存在的重要分子骨架，具有显著的抗病毒活性。通过分子修饰，开发了新型含碱基药物（NCD），对包括最近出现的 SARS-CoV-2 在内的多种病毒具有增强的抗病毒活性。本文详细研究了 2015 年至今 NCD 的重要进展，涵盖了其作用机制、药理学和抗病毒特性的各个方面。此外，本文还讨论了与本综述范围相关的抗病毒前药。通过研究 NCD 作为治疗多种病毒疾病的治疗药物的结构-活性关系和趋势，填补了这方面的知识空白，无论是已批准的药物、临床候选药物还是早期开发前景。此外，本文还强调了该研究领域的现状，并讨论了当前存在的局限性。
