Uberla K
Arzneimittelforschung. 1978;28(11a):2032-6.
Clinical pharmacology has its domain during phase I. The formalisation of phase I is not very advanced. Sometimes it is argued that the design of experiments during that phase is unnecessary. Just the opposite is true. Trying a new substance for the first time in man poses a special necessity for the design of experiments in a scientific context. Phase I is described in a formal way. The design of experiments with a single subject -- the first one to be exposed to a new substance -- is described. Finally Latin squares are dealt with as a useful tool for phase I.
临床药理学在I期有其应用领域。I期的规范化程度不是很高。有时有人认为该阶段的实验设计没有必要。事实恰恰相反。首次在人体中试验一种新物质，在科学背景下对实验设计提出了特殊要求。I期以一种正式的方式进行描述。描述了针对单个受试者（即第一个接触新物质的人）的实验设计。最后，拉丁方作为I期的一种有用工具进行了讨论。
