引入持续葡萄糖监测（CGM）是降低1型糖尿病战争难民儿童糖化血红蛋白（HbA1c）的关键因素。
Introduction of continuous glucose monitoring (CGM) is a key factor in decreasing HbA1c in war refugee children with type 1 diabetes.
作者信息
Neuman V, Vavra D, Drnkova L, Pruhova S, Plachy L, Kolouskova S, Obermannova B, Amaratunga S A, Konecna P, Vyzralkova J, Venhacova P, Pomahacova R, Paterova P, Stichova L, Skvor J, Kocourkova K, Romanova M, Vosahlo J, Strnadel J, Polockova K, Neumann D, Slavenko M, Sumnik Z
机构信息
Department of Pediatrics, 2(nd) Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
3(rd) Faculty of Medicine, Charles University, Prague, Czech Republic.
出版信息
Diabetes Res Clin Pract. 2024 Feb;208:111118. doi: 10.1016/j.diabres.2024.111118. Epub 2024 Feb 1.
AIMS
Our aim was to describe the changes in therapy and diabetes control in Ukrainian war refugee children with diabetes (CwD) during the first year of their stay in Czechia.
METHODS
A total of 124 CwD (62 male, 62 female) were enrolled into this observational study. Anthropometric, laboratory and diabetes management data were acquired at baseline and at 3 months intervals for 12 months. All CwD were offered a CGM device during their first visit. Generalized Estimating Equation models were fitted in order to estimate the dynamics of studied characteristics.
RESULTS
Median baseline HbA1c was 58 mmol/mol (IQR [48; 73]mmol/mol) (7.5 %, IQR[6.5;8.8]%). The HbA1c decreased significantly throughout the course of the study at a pace of - 2.2 mmol/mol (-0.2 %pt.) per visit (P = 0.01, CI[-3.2;-1.1]). The pace of the decrease in the average HbA1c was significantly higher in the group of CwD who received CGM in Czechia than in those who already had it from Ukraine by 2.9 mmol/mol (0.27 %pt.) per visit (P < 0.001, CI [-4.4; -1.3]).
CONCLUSIONS
The steepest decrease in HbA1c was observed in CwD with newly initiated CGM underlining its vital role in improving the glucose control of CwD regardless of their background.
目的
我们的目的是描述乌克兰糖尿病战争难民儿童（CwD）在捷克共和国停留的第一年中治疗和糖尿病控制的变化。
方法
共有124名CwD（62名男性，62名女性）被纳入这项观察性研究。在基线时以及在12个月内每隔3个月获取人体测量、实验室和糖尿病管理数据。所有CwD在首次就诊时都获得了一个连续血糖监测（CGM）设备。拟合广义估计方程模型以估计所研究特征的动态变化。
结果
基线糖化血红蛋白（HbA1c）中位数为58 mmol/mol（四分位间距[IQR][48; 73]mmol/mol）（7.5%，IQR[6.5; 8.8]%）。在整个研究过程中，HbA1c显著下降，每次就诊下降速度为-2.2 mmol/mol（-0.2个百分点）（P = 0.01，置信区间[CI][-3.2; -1.1]）。在捷克获得CGM的CwD组中，平均HbA1c的下降速度比那些在乌克兰就已拥有CGM的组显著快2.9 mmol/mol（0.27个百分点）每次就诊（P < 0.001，CI [-4.4; -1.3]）。
结论
在新开始使用CGM的CwD中观察到HbA1c下降最为显著，这突出了其在改善CwD血糖控制方面的关键作用，无论其背景如何。
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