Kocher R, Richter R
Arzneimittelforschung. 1978;28(9):1524-5.
In 15 lithium-treated psychotic patients, the following variables were examined over two years at 6-monthly intervals; seru lithium levels, serum electrolytes, thyroid function, urinary creatinine and urea, and clinical EEG. The mean serum lithium level was 0.64 mval/l and did not change during the two years. When compared to the pretreatment EEG, visual analysis did not indicate any specific potentials, focal signs, or asymmetrical phenomena such as have been reported in the literature. Only at the beginning of treatment could a small increase in unspecific, abnormal changes be demonstrated, which, however, decreased during the following 18-month period of investigation.
对15例接受锂盐治疗的精神病患者，在两年时间里每隔6个月对以下变量进行检查：血清锂水平、血清电解质、甲状腺功能、尿肌酐和尿素，以及临床脑电图。血清锂平均水平为0.64毫当量/升，在两年期间没有变化。与治疗前脑电图相比，视觉分析未显示出文献中所报道的任何特定电位、局灶性体征或不对称现象。仅在治疗开始时可显示非特异性异常变化有小幅增加，但在随后18个月的调查期间这种变化有所减少。
