四氧嘧啶诱导的糖尿病与松果体：对松果体N - 乙酰血清素、松果体褪黑素及血清褪黑素水平的不同影响。

Alloxan-induced diabetes and the pineal gland: differential effects on the levels of pineal N-acetylserotonin, pineal melatonin, and serum melatonin.

作者信息

Pang S F, Tang F, Tang P L

出版信息

J Pineal Res. 1985;2(1):79-85. doi: 10.1111/j.1600-079x.1985.tb00629.x.

DOI:10.1111/j.1600-079x.1985.tb00629.x

Abstract

Effects of alloxan treatment on the levels of pineal melatonin, pineal N-acetylserotonin, and serum melatonin were investigated. Male rats were housed under a photoperiod of 12 h light: 12 h darkness and a temperature of 23 +/- 3 degrees C. Three weeks after alloxan (170 mg/kg) or carrier injection (s.c.), the animals were killed at mid-light (1200 h) and mid-dark (2400 h). Pineal and serum indoles were extracted and quantified by radioimmunoassays. It was found that pineal levels of N-acetylserotonin in the diabetic rats were significantly higher (P less than 0.05) than those of the controls. Conversely, pineal and serum levels of melatonin in the control rats were significantly higher (P less than 0.05) than those of the alloxan-induced diabetics. Our results suggest that alloxan-induced diabetes may decrease pineal melatonin synthesis in rats by reducing the activity of hydroxyindole-O-methyltransferase, resulting in a decrease in pineal melatonin secretion.

摘要

研究了四氧嘧啶处理对松果体褪黑素、松果体N - 乙酰血清素和血清褪黑素水平的影响。雄性大鼠饲养在12小时光照：12小时黑暗的光周期和23±3摄氏度的温度下。在注射四氧嘧啶（170mg/kg）或载体（皮下注射）三周后，于光照中期（1200时）和黑暗中期（2400时）处死动物。通过放射免疫分析法提取并定量松果体和血清中的吲哚。发现糖尿病大鼠松果体中N - 乙酰血清素水平显著高于对照组（P < 0.05）。相反，对照大鼠松果体和血清中的褪黑素水平显著高于四氧嘧啶诱导的糖尿病大鼠（P < 0.05）。我们的结果表明，四氧嘧啶诱导的糖尿病可能通过降低羟基吲哚 - O - 甲基转移酶的活性来减少大鼠松果体褪黑素的合成，从而导致松果体褪黑素分泌减少。