Pang S F, Tang P L
Horm Res. 1983;17(4):228-34. doi: 10.1159/000179702.
Serum and pineal concentrations of melatonin and N-acetylserotonin in 4-month-old (adult) and 15-month-old (senile) male hamsters were studied. The animals were adapted under 12:12 h light:dark cycle for a minimum of 1 month before they were decapitated at mid-light and mid-dark. Melatonin and N-acetylserotonin in the pineal and serum were extracted and quantified by radioimmunoassay. Diurnal variations (p less than 0.05) were observed in the levels of pineal melatonin, pineal N-acetylserotonin and serum melatonin. There was, however, no day and night difference (p greater than 0.05) demonstrated in the levels of serum N-acetylserotonin and serum melatonin in the dark period and the level of serum melatonin in the light period of the adult hamster were higher (p less than 0.05) than those of the senile animal, but the levels of serum N-acetylserotonin in the two age-groups studied demonstrated no significant differences (p greater than 0.05). Our studies indicate that in the hamster, the synthesis and secretion of pineal melatonin decrease with aging.
研究了4月龄（成年）和15月龄（老年）雄性仓鼠血清和松果体中褪黑素和N - 乙酰血清素的浓度。在12:12小时光照：黑暗周期下适应至少1个月后，于光照中期和黑暗中期将动物断头。通过放射免疫测定法提取并定量松果体和血清中的褪黑素和N - 乙酰血清素。观察到松果体褪黑素、松果体N - 乙酰血清素和血清褪黑素水平存在昼夜变化（p小于0.05）。然而，成年仓鼠黑暗期血清N - 乙酰血清素和血清褪黑素水平以及光照期血清褪黑素水平没有昼夜差异（p大于0.05），且成年仓鼠光照期血清褪黑素水平高于老年动物（p小于0.05），但所研究的两个年龄组血清N - 乙酰血清素水平无显著差异（p大于0.05）。我们的研究表明，在仓鼠中，松果体褪黑素的合成和分泌随衰老而减少。
