亚硝酸钠治疗与无基质高铁血红蛋白溶液作为大鼠模型氰化物中毒解毒剂的比较。
Comparison of nitrite treatment and stroma-free methemoglobin solution as antidotes for cyanide poisoning in a rat model.
作者信息
Ten Eyck R P, Schaerdel A D, Ottinger W E
出版信息
J Toxicol Clin Toxicol. 1985;23(7-8):477-87. doi: 10.3109/15563658508990651.
The standard nitrite/thiosulfate regimen for cyanide poisoning was tested in our rat model. By modifying the treatment regimen and the nitrite solution an effective antidote against an LD90 of cyanide could be produced. However, this treatment was effective against two times the LD90 only when administered ten minutes prior to cyanide injection. These results are in marked contrast to our results with stroma-free methemoglobin solutions (SFMS) which showed SFMS to be a highly effective antidote against four times the LD90 when administered 30 seconds after an intravenous injection of cyanide. SFMS proved to be an effective antidote for two times the LD90 when administered up to sixty seconds after the cessation of respiration.
我们在大鼠模型中对氰化物中毒的标准亚硝酸盐/硫代硫酸盐治疗方案进行了测试。通过修改治疗方案和亚硝酸盐溶液，可以产生一种针对氰化物半数致死量（LD90）的有效解毒剂。然而，这种治疗方法仅在氰化物注射前10分钟给药时，对两倍LD90的剂量有效。这些结果与我们使用无基质高铁血红蛋白溶液（SFMS）的结果形成了显著对比，后者显示在静脉注射氰化物后30秒给药时，SFMS是一种针对四倍LD90的高效解毒剂。当在呼吸停止后长达60秒给药时，SFMS被证明是针对两倍LD90剂量的有效解毒剂。
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