Department of Thyroid Surgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China.
Department of Thyroid Surgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China.
Int Immunopharmacol. 2024 Mar 10;129:111605. doi: 10.1016/j.intimp.2024.111605. Epub 2024 Feb 4.
This study aimed to evaluate the associations between disulfidptosis related genes-SLC3A2, SLC7A11 and FLNB polymorphisms and risk of autoimmune thyroiditis (AIT).
Six SNPs in the SLC3A2, SLC7A11 and FLNB were genotyped in 650 AIT cases and 650 controls using a MassARRAY platform.
Minor alleles of SLC3A2-rs12794763, rs1059292 and FLNB-rs839240 might lead to a higher risk of AIT (p < 0.001), while SLC7A11-rs969319-C allele tends to decrease the risk of the disease (p = 0.006). Genetic model analysis showed that SLC3A2-rs12794763, SLC3A2-rs1059292 and FLNB-rs839240 polymorphisms were risk factors for AIT (p < 0.001); while SLC7A11-rs969319 showed a protective role for the disease in all genetic models (p < 0.005). Stratification analysis showed that SLC3A2-rs1059292 and rs12794763 were correlated with higher risk of AIT regardless of sex (p < 0.05). Moreover, FLNB-rs839240 exhibited higher risk of disease only in females (p < 0.05). By contrast, SLC7A11-rs969319 showed a protective role only in females (p < 0.05).
Our results shed new light on the association between disulfidptosis-related genes and AIT risk.
本研究旨在评估二硫键相关基因 SLC3A2、SLC7A11 和 FLNB 多态性与自身免疫性甲状腺炎（AIT）风险之间的关联。
使用 MassARRAY 平台对 650 例 AIT 病例和 650 例对照中的 SLC3A2、SLC7A11 和 FLNB 中的 6 个 SNP 进行基因分型。
SLC3A2-rs12794763、rs1059292 和 FLNB-rs839240 的次要等位基因可能导致 AIT 的风险增加（p<0.001），而 SLC7A11-rs969319-C 等位基因则倾向于降低疾病风险（p=0.006）。遗传模型分析表明，SLC3A2-rs12794763、SLC3A2-rs1059292 和 FLNB-rs839240 多态性是 AIT 的危险因素（p<0.001）；而 SLC7A11-rs969319 在所有遗传模型中均对疾病具有保护作用（p<0.005）。分层分析表明，SLC3A2-rs1059292 和 rs12794763 与 AIT 的高风险相关，无论性别如何（p<0.05）。此外，FLNB-rs839240 仅在女性中表现出更高的疾病风险（p<0.05）。相比之下，SLC7A11-rs969319 仅在女性中表现出保护作用（p<0.05）。
我们的结果为二硫键相关基因与 AIT 风险之间的关联提供了新的见解。
