Grewal Sonam, Tiwary Neha, Malik Gaurav, Garg Madhukar, Deswal Geeta, Chopra Bhawna, Grewal Ajmer Singh, Dhingra Ashwani K, Guarve Kumar
M.M. College of Pharmacy, M.M. (Deemed to be University), Mullana, Ambala, Haryana, India.
Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Pharm Nanotechnol. 2024 Jan 17. doi: 10.2174/0122117385271262231114075737.
For centuries, people have used herbal medicine to treat a diversity of health complications and as a natural substance, they have a favourable effect on our health. Herbal ingredients can be utilized as lead molecules in the innovation and development of a new drug. Flavonoids are a class of chemical compounds with diverse phenolic structures, and they are found in a wide variety of foods, including fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. Quercetin is the most prevalent polyphenolic bioflavonoid or flavonoid. Quercetin is found in many food products and has demonstrated a wide range of pharmacological activities, including the treatment of allergies, ocular diseases, metabolic ailments, inflammatory illnesses, cardiovascular ailments and arthritis. Quercetin has attracted interest as an emerging pharmacophore with the potential to significantly advance research and the development of novel therapeutic medicines for a variety of diseases. Despite having a huge therapeutic potential, these flavonoids have unfavourable pharmacokinetic characteristics, low bioavailability, and poor solubility, limiting their application in therapeutics. The objective of the current study is to present a new update on the major therapeutic uses of quercetin and other types of nanocarriers that contain quercetin to treat various ailments.
几个世纪以来,人们一直使用草药来治疗各种健康问题,作为一种天然物质,它们对我们的健康有积极影响。草药成分可作为新药创新和开发中的先导分子。黄酮类化合物是一类具有多种酚类结构的化合物,存在于多种食物中,包括水果、蔬菜、谷物、树皮、根、茎、花、茶和葡萄酒。槲皮素是最常见的多酚生物黄酮或黄酮类化合物。槲皮素存在于许多食品中,并已显示出广泛的药理活性,包括治疗过敏、眼部疾病、代谢疾病、炎症性疾病、心血管疾病和关节炎。槲皮素作为一种新兴的药效基团引起了人们的兴趣,它有可能显著推动针对多种疾病的新型治疗药物的研究和开发。尽管这些黄酮类化合物具有巨大的治疗潜力,但它们具有不良的药代动力学特征、低生物利用度和差的溶解度,限制了它们在治疗中的应用。本研究的目的是提供关于槲皮素的主要治疗用途以及其他含有槲皮素的纳米载体治疗各种疾病的最新信息。