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[波兰特定地区进行性肌营养不良的流行病学]

[Epidemiology of progressive muscular dystrophy in selected regions of Poland].

作者信息

Stepniak U

出版信息

Neurol Neurochir Pol. 1985 Sep-Oct;19(5):369-74.

PMID:3831791
Abstract

On the basis of the cases registered in the Outpatient Clinic for Muscular Diseases, Medical Academy in Warsaw including patients with progressive muscular dystrophy, and after an analysis of follow-up data the epidemiological indices and mutation indices were estimated in the population of Warsaw, Province of Warsaw and Province of Radom for the years 1960-1976. The calculated indices of incidence and prevalence of dystrophy and mutation were at the upper range of values reported in world literature. They were, however higher than those estimated in previous years in the same regions by Prot. The calculated index of natural abortions in mothers of patients with Duchenne's dystrophy was slightly higher than in the control group of women. Follow-up investigations show that the genetic counselling in this disease was insufficient in that time period.

摘要

根据华沙医学院肌肉疾病门诊登记的病例,包括进行性肌营养不良患者,并在分析随访数据后,估算了1960 - 1976年华沙市、华沙省和拉多姆省人群的流行病学指标和突变指标。计算得出的肌营养不良发病率、患病率及突变指标处于世界文献报道值的上限范围。然而,这些指标高于该地区前几年由某教授估算的数值。计算得出的杜兴氏肌营养不良患者母亲自然流产指标略高于女性对照组。随访调查表明,在那个时间段,针对这种疾病的遗传咨询不足。

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