Chang K, Chiou W L
Res Commun Chem Pathol Pharmacol. 1976 Feb;13(2):357-60.
The interaction between Parafilm and four tranquilizers in their neutral phosphate buffer solutions resulted in various degrees of loss of the drugs from the solutions. The values of loss ranged from 15 to 34% for chlorpromazine and 8 to 42% for butaperazine at the initial concentration range of 2 to 20 mug/ml at room temperature (22 +/- 1 degree C). Under the same conditions, the values of loss from saliva for these two drugs were fairly constant; about 25% and 17%, respectively. For diazepam and chlordiazepoxide, the losses from the buffer solution were below 5%.
在中性磷酸盐缓冲溶液中，Parafilm与四种镇静剂之间的相互作用导致溶液中药物出现不同程度的损失。在室温（22±1℃）下，当氯丙嗪初始浓度范围为2至20μg/ml时，损失值在15%至34%之间；丁酰拉嗪的损失值在8%至42%之间。在相同条件下，这两种药物在唾液中的损失值相当稳定，分别约为25%和17%。对于地西泮和氯氮卓，其在缓冲溶液中的损失低于5%。
