Nantes University, Centre Hospitalier Universitaire Nantes, Institut National de la Santé et de la Recherche Médicale, centre d'investigation clinique 1413, neuroscience Parkinson/French Clinical Research Infrastructure Network, Nantes, France.
NEJM Evid. 2023 Sep;2(9):EVIDe2300167. doi: 10.1056/EVIDe2300167. Epub 2023 Aug 22.
In recent decades, numerous studies have found that smoking or the intake of any form of nicotine, such as smokeless tobacco, exposure to environmental tobacco smoke, or even dietary sources such as peppers, reduces the risk of developing Parkinson's disease. Such observations suggest a potential disease-modifying effect of nicotine in Parkinson's disease. Many experimental studies, some of them supported by grants from the tobacco industry, have lent support for such a hypothesis.
近几十年来，许多研究发现，吸烟或摄入任何形式的尼古丁，如无烟烟草，暴露于环境烟草烟雾中，甚至是辣椒等饮食来源，都可以降低帕金森病的发病风险。这些观察结果表明尼古丁对帕金森病可能具有潜在的疾病修饰作用。许多实验研究，其中一些得到了烟草业的资助，为这一假设提供了支持。
