Medical School of Yan'an University, Shaanxi, China.
Yan'an University School Hospital, Shaanxi, China.
Public Health. 2024 Feb;227:267-273. doi: 10.1016/j.puhe.2023.12.001. Epub 2024 Feb 5.
Studies related to air pollutants and spontaneous abortion in urban northwestern China are scarce, and the main exposure windows of pollutants acting on pregnant women are unclear.
Case-control study.
Data were collected from pregnant women in Tongchuan City from 2018 to 2019. A total of 289 cases of spontaneous abortion and 1156 cases of full-term labor were included and analyzed using a case-control study. Logistic regression models were developed to explore the relationship between air pollutants and spontaneous abortion after Chi square analysis and Air pollutant description.
O (odds ratio [OR] = 1.028) is a risk factor for spontaneous abortion throughout pregnancy. PM (OR = 1.015), PM (OR = 1.010), SO (OR = 1.026), and NO (OR = 1.028) are risk factors for spontaneous abortion in the 30 days before the last menstrual period. PM (OR = 1.015), PM (OR = 1.013), SO (OR = 1.036), and NO (OR = 1.033) are risk factors for spontaneous abortion in the 30-60 days before the last menstrual period. PM (OR = 1.028), PM (OR = 1.013), SO (OR = 1.035), and NO (OR = 1.059) are risk factors for spontaneous abortion in the 60-90 days before the last menstrual period.
Exposure to high levels of air pollutants may be a cause of increased risk of spontaneous abortion, especially in the first trimester of the last menstrual period.
中国西北部城市有关空气污染物与自然流产的研究较为匮乏，且污染物作用于孕妇的主要暴露窗口尚不明确。
病例对照研究。
本研究数据来自于 2018 年至 2019 年铜川市的孕妇。共纳入 289 例自然流产病例和 1156 例足月分娩病例，并采用病例对照研究进行分析。采用卡方分析和空气污染物描述进行逻辑回归模型构建，以探讨空气污染物与自然流产之间的关系。
整个孕期中，O（比值比 [OR] = 1.028）是自然流产的危险因素。PM（OR = 1.015）、PM（OR = 1.010）、SO（OR = 1.026）和 NO（OR = 1.028）是末次月经前 30 天自然流产的危险因素。PM（OR = 1.015）、PM（OR = 1.013）、SO（OR = 1.036）和 NO（OR = 1.033）是末次月经前 30-60 天自然流产的危险因素。PM（OR = 1.028）、PM（OR = 1.013）、SO（OR = 1.035）和 NO（OR = 1.059）是末次月经前 60-90 天自然流产的危险因素。
暴露于高水平的空气污染物可能是增加自然流产风险的一个原因，尤其是在末次月经的前三个月。
