帕金森病与心脏和血管疾病之间的因果关系：两样本孟德尔随机化研究。
Causal Relationship between Parkinson's Disease with Heart and Vascular Disease: A Two-Sample Mendelian Randomization Study.
机构信息
Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China,
Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
出版信息
Eur Neurol. 2024;87(1):11-16. doi: 10.1159/000536484. Epub 2024 Feb 6.
INTRODUCTION
The aim of this study was to investigate the causal relationship between Parkinson's disease (PD) and myocardial infarction (MI), atrial fibrillation and flutter (AF), and venous thromboembolism (VTE) by Mendelian randomization (MR) analysis.
METHODS
By using data from publicly available genome-wide association studies from databases, single nucleotide polymorphisms were screened as instrumental variables, and the MR analysis was finished by inverse-variance weighted (IVW), MR-egger, weighted median methods.
RESULTS
The primary IVW method showed a negative association between genetically predicted PD and risk of MI (OR = 0.9989; 95% CI: 0.9980-0.9998; p = 0.02). However, PD was not significantly associated with AF or VTE.
CONCLUSION
This study suggests a negative association between PD with MI, which implies that PD has a protective effect on MI.
简介
本研究旨在通过孟德尔随机化（MR）分析，探讨帕金森病（PD）与心肌梗死（MI）、心房颤动和扑动（AF）以及静脉血栓栓塞症（VTE）之间的因果关系。
方法
利用数据库中公开的全基因组关联研究数据，筛选单核苷酸多态性作为工具变量，并采用逆方差加权（IVW）、MR-egger、加权中位数方法进行 MR 分析。
结果
主要的 IVW 方法表明，遗传预测的 PD 与 MI 风险呈负相关（OR=0.9989；95%CI：0.9980-0.9998；p=0.02）。然而，PD 与 AF 或 VTE 无显著相关性。
结论
本研究提示 PD 与 MI 之间存在负相关，这表明 PD 对 MI 具有保护作用。
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