从6-(3-氟吡啶-4-基)噻吩并[3,2-]嘧啶-4(3H)-酮衍生物中发现一种强效且选择性的细胞分裂周期7抑制剂，作为口服活性抗肿瘤药物。 - Suppr

Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl)thieno[3,2-]pyrimidin-4(3)-one derivatives as an orally active antitumor agent.

作者信息

Fu Mingwei, Ge Min, Yang Wanxiang, Hu Chunchen, Li Xiaowei, Wang Yuanjiang, Gou Shaohua

机构信息

Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.

Zenji Research Laboratories, Nanjing 211189, China.

出版信息

Acta Pharm Sin B. 2024 Feb;14(2):893-896. doi: 10.1016/j.apsb.2023.11.026. Epub 2023 Nov 27.

DOI:10.1016/j.apsb.2023.11.026

PMID:38322352

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10840422/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d188/10840422/c83ae35f6dc0/gr1.jpg

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Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl)thieno[3,2-]pyrimidin-4(3)-one derivatives as an orally active antitumor agent.从6-(3-氟吡啶-4-基)噻吩并[3,2-]嘧啶-4(3H)-酮衍生物中发现一种强效且选择性的细胞分裂周期7抑制剂，作为口服活性抗肿瘤药物。

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Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl)thieno[3,2-]pyrimidin-4(3)-one derivatives as an orally active antitumor agent.

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