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[多发性硬化症的脊髓型。脑磁共振检查的价值与批判。附4例报告]

[Spinal forms of multiple sclerosis. Value and criticism of examination by cerebral magnetic resonance. Apropos of 4 cases].

作者信息

Lyon-Caen O, Iba-Zizen M T, Tamraz J, Bousser M G, Cabanis E A, Lhermitte F

出版信息

Rev Neurol (Paris). 1985;141(12):793-801.

PMID:3832298
Abstract

Four observations of spinal forms of multiple sclerosis (MS) have been studied by Magnetic Resonance Imaging (MRI) (Magniscan Thomson CGR 0,15 and 0,5 T). They concerned 3 females and 1 male, aged between 29 and 60. Evolution of MS varied between 1 year and 9 years. There were no familial story of neurological illness; there were no signs and symptoms of visual, oculo-motor, labyrinthic and cerebellar disorders in the past. VEP were abnormal in 2 cases (no 1, 3), BAEP in 1 case (no 2). CSF examination showed increased gamma globulins with an oligoclonal pattern in 2 cases (no 3,4). CT Scan performed with iodine contrast injection was normal in 3 cases (no 2,3,4). In all the cases, MRI using T2 weighted-SE sequences, showed high signal lesions in the white matter of the brain and/or the cerebellum, and periventricular patchy white matter lesions. It seems to be no relationship between the duration of MS and the number of abnormal high signals areas, but more important series are necessary to confirm or not such a result. These lesions seem to be without aetiological specificity. They have to be discussed according to the clinical biological, electro-physiological data and sometimes others neuroradiological procedures.

摘要

利用磁共振成像(MRI)(Magniscan Thomson CGR 0.15和0.5T)对4例脊髓型多发性硬化症(MS)患者进行了研究。患者包括3名女性和1名男性,年龄在29岁至60岁之间。MS病程在1年至9年之间不等。无神经疾病家族史;既往无视觉、动眼、迷路及小脑疾病的体征和症状。2例患者(病例1、3)视觉诱发电位(VEP)异常,1例患者(病例2)脑干听觉诱发电位(BAEP)异常。2例患者(病例3、4)脑脊液检查显示γ球蛋白升高并呈寡克隆带型。3例患者(病例2、3、4)静脉注射碘造影剂后的CT扫描结果正常。在所有病例中,使用T2加权自旋回波序列的MRI显示脑白质和/或小脑白质有高信号病变,以及脑室周围斑片状白质病变。MS病程与异常高信号区域的数量之间似乎没有关系,但需要更多病例来证实或否定这一结果。这些病变似乎没有病因学特异性。必须根据临床生物学、电生理数据以及有时其他神经放射学检查结果进行讨论。

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Rev Neurol (Paris). 1985;141(12):793-801.
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