Yang Wei, Gong Yuxi, Wang Yansong, Wu Chao, Zhang Xiangyu, Li Jinlian, Wu Dongmei
College of Pharmacy, Jiamusi University Jiamusi Heilongjiang 154007 P. R. China
Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation, Jiamusi University Jiamusi 154007 P. R. China.
RSC Adv. 2024 Feb 6;14(7):4880-4889. doi: 10.1039/d3ra08526k. eCollection 2024 Jan 31.
Microencapsulation has been widely used to protect essential oils, facilitating their application in cosmetics. In this study, gelatin, gum arabic and -butyl cyanoacrylate were used as wall materials, and composite microcapsules of tea tree essential oil (TTO) were prepared using a combination of composite coagulation and polymerization methods. When the ratio of gelatin to gum arabic is 1 : 1, the ratio of TTO to -butyl cyanoacrylate is 4 : 1, the curing time is 10 h, and the encapsulation efficiency (EE) under these conditions is 73.61%. Morphological observation showed that the composite capsule was a micron-sized spherical particle with an average particle size of 10.51 μm, and Fourier transform infrared spectroscopy (FT-IR) confirmed a complex coagulation reaction between gelatin and gum arabic, and the disappearance of the -butyl cyanoacrylate peak indicated that the film was formed in a condensation layer. The thermogravimetric analysis (TGA) results showed that the composite capsule greatly improved the thermal stability of TTO. Rheological testing showed that the viscosity and viscoelasticity of the surface composite capsules have been improved. In addition, the composite capsule showed good stability in the osmotic environment and has good sustained-release performance and antioxidant capacity in the average human skin environment.
微胶囊化已被广泛用于保护香精油，便于其在化妆品中的应用。在本研究中，使用明胶、阿拉伯树胶和氰基丙烯酸正丁酯作为壁材，采用复合凝聚和聚合方法相结合制备了茶树精油（TTO）复合微胶囊。当明胶与阿拉伯树胶的比例为1∶1、TTO与氰基丙烯酸正丁酯的比例为4∶1、固化时间为10 h时，在此条件下的包封率（EE）为73.61%。形态学观察表明，复合胶囊为微米级球形颗粒，平均粒径为10.51μm，傅里叶变换红外光谱（FT-IR）证实了明胶与阿拉伯树胶之间发生了复合凝聚反应，氰基丙烯酸正丁酯峰的消失表明在凝聚层中形成了薄膜。热重分析（TGA）结果表明，复合胶囊极大地提高了TTO的热稳定性。流变学测试表明，表面复合胶囊的粘度和粘弹性得到了提高。此外，复合胶囊在渗透环境中表现出良好的稳定性，在普通人体皮肤环境中具有良好的缓释性能和抗氧化能力。
