具有两个手性亚基的异双功能轮烷——合成及其在不对称有机催化中的应用
Heterobifunctional rotaxanes featuring two chiral subunits - synthesis and application in asymmetric organocatalysis.
作者信息
Kauerhof Dana, Riebe Jan, Vonnemann Christoph J, Thiele Maike, Jansen Dennis, Niemeyer Jochen
机构信息
Faculty of Chemistry (Organic Chemistry) and Centre of Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Universitätsstr. 7, 45141 Essen, Germany.
出版信息
Chem Commun (Camb). 2024 Feb 22;60(17):2393-2396. doi: 10.1039/d3cc05482a.
PMID:38323328
Abstract
Rotaxanes can serve as scaffolds for the generation of bifunctional catalysts. We have now generated acid-base functionalized rotaxanes featuring two chiral subunits. The mechanical bond leads to increased reaction rates and also to strongly altered enantioselectivites in comparison to the non-interlocked control catalysts.
摘要
轮烷可作为生成双功能催化剂的支架。我们现已制备出具有两个手性亚基的酸碱功能化轮烷。与非互锁的对照催化剂相比，机械键导致反应速率增加，并且对映选择性也发生了显著改变。
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