Chen Z Q, Chan Q I, Par C C, Qu J Y
Scand J Work Environ Health. 1985;11 Suppl 4:26-8.
The peripheral nerve conduction velocity between the wrist and elbow of the right upper limb and the relationship between this parameter and biochemical parameters for workers occupationally exposed to lead were studied. The results showed that nerve conduction velocity could be altered by lead exposure. The nerve conduction velocity was decreased when the exposure level was 0.0652 mg/m3 (time-weighed average), and it slowed further in proportion to increasing exposure levels. There was a negative correlation between the nerve conduction velocity and the length of exposure. A decrease in the nerve conduction velocity was noted after less than three years of exposure to lead. There was a close relationship between the nerve conduction velocity and the level of lead in the blood; the nerve conduction velocity decreased proportionally with increasing blood lead levels. The blood lead level associated with a change in the nerve conduction velocity was less than 40 micrograms/100 ml (less than 1.9 mumol/l). No correlation between the nerve conduction velocity and the amount of metabolites of porphyrin was found. The measurement of nerve conduction velocity can be used as one of the sensitive criteria for the early detection of the toxic effects of lead.
对职业性接触铅的工人右上肢手腕与肘部之间的周围神经传导速度及其与生化参数的关系进行了研究。结果表明，铅暴露可改变神经传导速度。当暴露水平为0.0652毫克/立方米（时间加权平均值）时，神经传导速度降低，且随着暴露水平的增加而进一步减慢。神经传导速度与暴露时长呈负相关。接触铅不到三年后即观察到神经传导速度下降。神经传导速度与血铅水平密切相关；神经传导速度随血铅水平升高而成比例下降。与神经传导速度变化相关的血铅水平低于40微克/100毫升（低于1.9微摩尔/升）。未发现神经传导速度与卟啉代谢产物量之间存在相关性。神经传导速度的测量可作为早期检测铅中毒效应的敏感标准之一。
