Suppr
超能文献

使用网络分析识别重度抑郁症患者的核心残留症状并阐明其与预后的关联：一项基于中国全国队列的研究

Identifying the core residual symptom in patients with major depressive disorder using network analysis and illustrating its association with prognosis: A study based on the national cohorts in China.

作者信息

Zhou Jingjing, Zhou Jia, Feng Zizhao, Feng Lei, Xiao Le, Chen Xu, Yang Jian, Feng Yuan, Wang Gang

机构信息

Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.

出版信息

Gen Hosp Psychiatry. 2024 Mar-Apr;87:68-76. doi: 10.1016/j.genhosppsych.2024.01.012. Epub 2024 Feb 1.

DOI:10.1016/j.genhosppsych.2024.01.012

PMID:38325144

Abstract

OBJECTIVE

To identify the core residual symptom of MDD and assess its relationship with patients' long-term outcomes.

METHOD

All patients were administered antidepressants during the acute phase and treated continuously. The 521 patients remitted at month 6 of a multicenter prospective project were included. Remission was defined as a Quick Inventory of Depressive Symptoms-Self-Report total score of ≤5. Functional impairments were measured with the Sheehan Disability Scale, quality of life with the Quality of Life Enjoyment and Satisfaction Questionnaire - short form, and family burden with the Family Burden Scale of Disease. Visits were scheduled at baseline, weeks 2, 8, 12, and month 6.

RESULTS

Difficulty with concentration/decision making was the core residual symptom of MDD, determined with the centrality measure of network analysis. It was positively associated with functional impairments and family burden (r = 0.35, P < 0.01 and r = 0.31, P < 0.01, respectively) and negatively associated with life satisfaction (r = -0.29, P < 0.01). The exhibition of this residual symptom was associated with a family history of psychiatric disorders (OR = 2.610 [1.242-5.485]).

CONCLUSIONS

The core residual symptom of MDD, difficulty with concentration/decision making, is associated with poorer social functioning, heavier family burden, and lower life satisfaction. Early detection and intervention of this symptom may be beneficial.

CLINICAL TRIALS REGISTRATION NUMBER

(Chinese Clinical Trials.gov identifier) ChiCTR-OOC-17012566 and ChiCTR-INR-17012574.

摘要

目的

确定重度抑郁症（MDD）的核心残留症状，并评估其与患者长期预后的关系。

方法

所有患者在急性期均接受抗抑郁药治疗并持续治疗。纳入了一个多中心前瞻性项目中在第6个月缓解的521例患者。缓解定义为抑郁症状快速自评量表总分≤5分。使用希恩残疾量表测量功能损害，使用生活享受与满意度问卷简表测量生活质量，使用疾病家庭负担量表测量家庭负担。在基线、第2周、第8周、第12周和第6个月安排随访。

结果

注意力不集中/决策困难是MDD的核心残留症状，通过网络分析的中心性测量确定。它与功能损害和家庭负担呈正相关（r分别为0.35，P<0.01和r为0.31，P<0.01），与生活满意度呈负相关（r=-0.29，P<0.01）。这种残留症状的出现与精神疾病家族史相关（OR=2.610[1.242-5.485]）。