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Newly identified structures of trace-amine associated receptor-1 (TAAR1) will aid discovery of next generation neuropsychiatric drugs.

作者信息

Nair Pramod C, Shajan Britto, Bastiampillai Tarun

机构信息

Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

Flinders Health and Medical Research Institute (FHMRI) College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

出版信息

Mol Psychiatry. 2024 Jun;29(6):1925-1928. doi: 10.1038/s41380-024-02466-z. Epub 2024 Feb 7.

DOI:10.1038/s41380-024-02466-z
PMID:38326558
Abstract
摘要

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Newly identified structures of trace-amine associated receptor-1 (TAAR1) will aid discovery of next generation neuropsychiatric drugs.新发现的痕量胺相关受体1（TAAR1）结构将有助于新一代神经精神药物的研发。
Mol Psychiatry. 2024 Jun;29(6):1925-1928. doi: 10.1038/s41380-024-02466-z. Epub 2024 Feb 7.
2
AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1.AlphaFold 加速了针对痕量胺相关受体 1 的精神药物激动剂的发现。
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3
Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands.人类和小鼠的痕量胺相关受体1对内源性单胺和咪唑啉受体配体具有不同的药理学特性。
Biochem J. 2009 Oct 23;424(1):39-45. doi: 10.1042/BJ20090998.
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TAAR1 and Psychostimulant Addiction.TAAR1 与精神兴奋剂成瘾。
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Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases.痕量胺相关受体 1：神经精神疾病的多模式治疗靶点。
Expert Opin Ther Targets. 2018 Jun;22(6):513-526. doi: 10.1080/14728222.2018.1480723. Epub 2018 Jun 5.
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Computational Methods for the Discovery and Optimization of TAAR1 and TAAR5 Ligands.TAAR1 和 TAAR5 配体的发现和优化的计算方法。
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In-vivo pharmacology of Trace-Amine Associated Receptor 1.痕量胺相关受体1的体内药理学
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In Vitro Characterization of Psychoactive Substances at Rat, Mouse, and Human Trace Amine-Associated Receptor 1.精神活性物质对大鼠、小鼠和人类痕量胺相关受体1的体外特性研究
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Ligand functional selectivity advances our understanding of drug mechanisms and drug discovery.配体功能选择性推动了我们对药物作用机制和药物发现的理解。
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Trace amine associated receptor 1 (TAAR1) modulators: a patent review (2010-present).痕量胺相关受体 1（TAAR1）调节剂：专利审查（2010 年至今）。
Expert Opin Ther Pat. 2020 Feb;30(2):137-145. doi: 10.1080/13543776.2020.1708900. Epub 2019 Dec 25.

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Structure-based identification of bioactive compounds as trace amine-associated receptor 1 agonists for the therapeutic management of major depressive disorder.基于结构鉴定生物活性化合物作为痕量胺相关受体1激动剂用于重度抑郁症的治疗管理
PLoS One. 2025 Aug 5;20(8):e0327890. doi: 10.1371/journal.pone.0327890. eCollection 2025.
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Chemosensory Receptors in Vertebrates: Structure and Computational Modeling Insights.脊椎动物的化学感受器：结构与计算建模见解
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Unlocking the secrets of trace amine-associated receptor 1 agonists: new horizon in neuropsychiatric treatment.

本文引用的文献

1
Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.TAAR1 的结构和信号机制使选择性激动剂设计成为可能。
Cell. 2023 Nov 22;186(24):5347-5362.e24. doi: 10.1016/j.cell.2023.10.014. Epub 2023 Nov 13.
2
Recognition of methamphetamine and other amines by trace amine receptor TAAR1.痕量胺受体 TAAR1 识别甲基苯丙胺和其他胺类物质。
Nature. 2023 Dec;624(7992):663-671. doi: 10.1038/s41586-023-06775-1. Epub 2023 Nov 7.
3
Ligand recognition and G-protein coupling of trace amine receptor TAAR1.痕量胺受体 TAAR1 的配体识别和 G 蛋白偶联。
揭开痕量胺相关受体1激动剂的秘密：神经精神疾病治疗的新视野。
Front Psychiatry. 2024 Oct 31;15:1464550. doi: 10.3389/fpsyt.2024.1464550. eCollection 2024.
4
Trace amine-associated receptor 1 (TAAR1) agonism for psychosis: a living systematic review and meta-analysis of human and non-human data.用于治疗精神病的痕量胺相关受体1（TAAR1）激动剂：对人类和非人类数据的实时系统评价和荟萃分析。
Wellcome Open Res. 2024 Apr 11;9:182. doi: 10.12688/wellcomeopenres.21302.1. eCollection 2024.
5
Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations.痕量胺相关受体 1：单核苷酸变异对地理分布不同人群结构-功能的预测影响。
Hum Genomics. 2024 Jun 11;18(1):61. doi: 10.1186/s40246-024-00620-w.
Nature. 2023 Dec;624(7992):672-681. doi: 10.1038/s41586-023-06804-z. Epub 2023 Nov 7.
4
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial.MDMA 辅助治疗中重度 PTSD：一项随机、安慰剂对照的 3 期试验。
Nat Med. 2023 Oct;29(10):2473-2480. doi: 10.1038/s41591-023-02565-4. Epub 2023 Sep 14.
5
Psychedelics reopen the social reward learning critical period.迷幻剂重新开启社会奖励学习的关键期。
Nature. 2023 Jun;618(7966):790-798. doi: 10.1038/s41586-023-06204-3. Epub 2023 Jun 14.
6
Timing is key for behavioural benefits of psychedelics.时机是迷幻药产生行为益处的关键。
Nature. 2023 Jun;618(7966):677-678. doi: 10.1038/d41586-023-01869-2.
7
Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders.痕胺相关受体 1（TAAR1）激动剂作为精神分裂症和相关障碍的新治疗策略。
Trends Neurosci. 2023 Jan;46(1):60-74. doi: 10.1016/j.tins.2022.10.010. Epub 2022 Nov 8.
8
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression.单次剂量裸盖菇素治疗难治性重度抑郁症发作。
N Engl J Med. 2022 Nov 3;387(18):1637-1648. doi: 10.1056/NEJMoa2206443.
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Binding of SEP-363856 within TAAR1 and the 5HT receptor: implications for the design of novel antipsychotic drugs.SEP-363856与TAAR1及5-羟色胺受体的结合：对新型抗精神病药物设计的启示
Mol Psychiatry. 2022 Jan;27(1):88-94. doi: 10.1038/s41380-021-01250-7. Epub 2021 Aug 10.
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A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia.一种用于治疗精神分裂症的非 D2 受体结合药物。
N Engl J Med. 2020 Apr 16;382(16):1497-1506. doi: 10.1056/NEJMoa1911772.