Yan Denghong, Wen Shun, Xing Yunxin, Bu Jie, Shen Kun
School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
J Org Chem. 2024 Feb 16;89(4):2223-2231. doi: 10.1021/acs.joc.3c02120. Epub 2024 Feb 7.
A nickel-catalyzed reductive -arylative cyclization of alkynyl enones with aryl halides has been developed. The reaction avoids the use of stoichiometric organometallic reagents and has a broad reaction scope and high functional group tolerance. This method offers an efficient way to access a variety of synthetically useful carbocycles that are widely found in many natural products and biologically active molecules.
已开发出一种镍催化的炔基烯酮与芳基卤化物的还原芳基化环化反应。该反应避免使用化学计量的有机金属试剂，具有广泛的反应范围和高官能团耐受性。此方法提供了一种有效途径来获得多种在许多天然产物和生物活性分子中广泛存在的合成有用的碳环。
