State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.
Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
FEBS J. 2024 Aug;291(16):3597-3603. doi: 10.1111/febs.17089. Epub 2024 Feb 8.
Immunoglobulin A (IgA) plays a crucial role in the human immune system, particularly in mucosal immunity. IgA antibodies that target the mucosal surface are made up of two to five IgA monomers linked together by the joining chain, forming polymeric molecules. These IgA polymers are transported across mucosal epithelial cells by the polymeric immunoglobulin receptor pIgR, resulting in the formation of secretory IgA (SIgA). This review aims to explore recent advancements in our molecular understanding of IgA, with a specific focus on SIgA, and the interaction between IgA and pathogen molecules.
免疫球蛋白 A（IgA）在人体免疫系统中起着至关重要的作用，特别是在黏膜免疫中。针对黏膜表面的 IgA 抗体由两个到五个 IgA 单体通过连接链连接在一起形成多聚体分子。这些 IgA 多聚体通过多聚免疫球蛋白受体 pIgR 穿过黏膜上皮细胞运输，形成分泌型 IgA（SIgA）。本综述旨在探讨我们对 IgA 的分子理解方面的最新进展，特别关注 SIgA 以及 IgA 与病原体分子之间的相互作用。
