Çınar Abdulkadir Can, Küpeli Çınar Ayça, Güçlü Hande
Department of Ophtalmology, Trakya University School of Medicine, 22000, Edirne, Turkey.
Int Ophthalmol. 2024 Feb 8;44(1):31. doi: 10.1007/s10792-024-02947-8.
The aim of the study is to evaluate the effects of diabetic retinopathy and intravitreal injections on the corneal, limbal and scleral areas.
Patients with diabetes mellitus at different diagnosis and treatment levels were compared among themselves and with the control group in terms of corneal, limbal and scleral aspects with the help of anterior segment optical coherence tomography. In addition, clinical tests such as tear break-up time, Schirmer test-I and ocular surface disease index questionnaire were applied to the patients and the difference between the groups was investigated.
When the groups were examined in terms of BUT, SCH-I and OSDI, there was a statistically significant difference between control group and diabetic group(p < 0.05). In the limbal region, all measurements are higher than in patients with diabetic eye involvement. Thinning was detected in the scleral area with intravitreal injection (p < 0.05).
It should be known that DM may cause undesirable changes in the limbal region, and the importance of non-invasive detection with AS-OCT should not be forgotten. Since intravitreal injections for DME cause thinning of the sclera, it can cause various complications, and it may be recommended to change the quadrant in repetitive injection applications.
本研究旨在评估糖尿病视网膜病变和玻璃体内注射对角膜、角膜缘和巩膜区域的影响。
借助眼前节光学相干断层扫描技术，对处于不同诊断和治疗水平的糖尿病患者自身以及与对照组在角膜、角膜缘和巩膜方面进行比较。此外，对患者进行泪膜破裂时间、Schirmer试验-I和眼表疾病指数问卷等临床检查，并研究组间差异。
在泪膜破裂时间（BUT）、Schirmer试验-I（SCH-I）和眼表疾病指数（OSDI）方面对各组进行检查时，对照组与糖尿病组之间存在统计学显著差异（p < 0.05）。在角膜缘区域，所有测量值均高于糖尿病眼部受累患者。玻璃体内注射后在巩膜区域检测到变薄（p < 0.05）。
应知晓糖尿病可能会在角膜缘区域引起不良变化，且不应忘记眼前节光学相干断层扫描（AS-OCT）进行无创检测的重要性。由于糖尿病性黄斑水肿的玻璃体内注射会导致巩膜变薄，可能会引发各种并发症，对于重复性注射应用，建议改变注射象限。
