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Allogeneic hematopoietic cell transplantation for VEXAS syndrome: results of a multicenter study of the EBMT.

作者信息

Gurnari Carmelo, Koster Linda, Baaij Laurien, Heiblig Mael, Yakoub-Agha Ibrahim, Collin Matthew, Passweg Jakob, Bulabois Claude E, Khan Anjum, Loschi Michael, Carnevale-Schianca Fabrizio, Crisà Elena, Caravelli Daniela, Kuball Jürgen, Saraceni Francesco, Olivieri Attilio, Rambaldi Alessandro, Kulasekararaj Austin G, Hayden Patrick J, Badoglio Manuela, Onida Francesco, Scheid Christof, Franceschini Franco, Mekinian Arsène, Savic Sinisa, Voso Maria Teresa, Drozd-Sokolowska Joanna, Snowden John A, Raj Kavita, Alexander Tobias, Robin Marie, Greco Raffaella, McLornan Donal P

机构信息

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.

Translational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.

出版信息

Blood Adv. 2024 Mar 26;8(6):1444-1448. doi: 10.1182/bloodadvances.2023012478.

DOI:10.1182/bloodadvances.2023012478
PMID:38330178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10955646/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/10955646/8b3c360cf383/BLOODA_ADV-2023-012478-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/10955646/8b3c360cf383/BLOODA_ADV-2023-012478-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/10955646/8b3c360cf383/BLOODA_ADV-2023-012478-gr1.jpg

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本文引用的文献

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Diagnostic capabilities, clinical features, and longitudinal UBA1 clonal dynamics of a nationwide VEXAS cohort.一个全国性VEXAS队列的诊断能力、临床特征及UBA1基因的纵向克隆动态变化
Am J Hematol. 2024 Feb;99(2):254-262. doi: 10.1002/ajh.27169. Epub 2023 Dec 18.
2
VEXAS syndrome: Clinical, hematologic features and a practical approach to diagnosis and management.VEXAS 综合征:临床、血液学特征及诊断和管理的实用方法。
Am J Hematol. 2024 Feb;99(2):284-299. doi: 10.1002/ajh.27156. Epub 2023 Nov 11.
3
Spectrum of clonal hematopoiesis in VEXAS syndrome.
VEXAS:当前认识与新兴治疗策略综述
Front Immunol. 2025 Jul 28;16:1644404. doi: 10.3389/fimmu.2025.1644404. eCollection 2025.
4
A cross-sectional survey on VEXAS syndrome: insights from a global expert panel.一项关于VEXAS综合征的横断面调查:来自全球专家小组的见解。
Clin Rheumatol. 2025 Aug 9. doi: 10.1007/s10067-025-07617-3.
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Exploring patient-reported outcomes and morbidity burden of patients with VEXAS syndrome: a scoping review.探索VEXAS综合征患者的患者报告结局和发病负担:一项范围综述
EClinicalMedicine. 2025 Jul 12;86:103354. doi: 10.1016/j.eclinm.2025.103354. eCollection 2025 Aug.
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The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis.单基因系统性血管炎的发病机制、临床表现及治疗
Nat Rev Rheumatol. 2025 May 14. doi: 10.1038/s41584-025-01250-9.
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Erythroid-stimulating agents in VEXAS syndrome: A retrospective study from an Italian multicentre cohort.VEXAS综合征中的促红细胞生成剂:一项来自意大利多中心队列的回顾性研究。
Br J Haematol. 2025 May 13;207(1):273-7. doi: 10.1111/bjh.20157.
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Myeloid neoplasm inspired intensive therapy in VEXAS syndrome: A single-centre experience.骨髓肿瘤激发了VEXAS综合征的强化治疗:单中心经验。
Br J Haematol. 2025 Jun;206(6):1683-1688. doi: 10.1111/bjh.20067. Epub 2025 Apr 8.
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Nat Med. 2025 Apr 7. doi: 10.1038/s41591-025-03623-9.
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Efficacy and safety of conventional disease-modifying antirheumatic drugs in VEXAS syndrome: real-world data from the international AIDA network.传统改善病情抗风湿药物在VEXAS综合征中的疗效和安全性:来自国际AIDA网络的真实世界数据。
Front Pharmacol. 2025 Mar 7;16:1539756. doi: 10.3389/fphar.2025.1539756. eCollection 2025.
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Autoimmune manifestations in VEXAS: Opportunities for integration and pitfalls to interpretation.VEXAS 相关自身免疫表现:整合的机会与解读的陷阱。
J Allergy Clin Immunol. 2023 May;151(5):1204-1214. doi: 10.1016/j.jaci.2023.02.017. Epub 2023 Mar 21.
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From bone marrow failure syndromes to VEXAS: Disentangling clonal hematopoiesis, immune system, and molecular drivers.从骨髓衰竭综合征到VEXAS:厘清克隆性造血、免疫系统及分子驱动因素
Leuk Res. 2023 Apr;127:107038. doi: 10.1016/j.leukres.2023.107038. Epub 2023 Feb 11.
6
Reduced intensity conditioning allogeneic hematopoietic stem cell transplantation in VEXAS syndrome: Data from a prospective series of patients.VEXAS综合征中减低强度预处理异基因造血干细胞移植:来自一系列前瞻性患者的数据
Am J Hematol. 2023 Feb;98(2):E28-E31. doi: 10.1002/ajh.26786. Epub 2022 Dec 1.
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Screening in Sweet Syndrome With Hematological Neoplasms Reveals a Novel Association Between VEXAS and Chronic Myelomonocytic Leukemia.血液系统肿瘤患者Sweet综合征筛查揭示VEXAS与慢性粒单核细胞白血病之间的新关联。
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Br J Haematol. 2022 Dec;199(5):777-781. doi: 10.1111/bjh.18488. Epub 2022 Oct 2.
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Case report: Up-front allogeneic stem cell transplantation in a patient with the VEXAS syndrome.病例报告:一名患有VEXAS综合征的患者接受 upfront 异基因干细胞移植。
Br J Haematol. 2022 Nov;199(3):e12-e15. doi: 10.1111/bjh.18424. Epub 2022 Aug 29.
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Update on VEXAS and role of allogeneic bone marrow transplant: Considerations on behalf of the Chronic Malignancies Working Party of the EBMT.VEXAS 最新进展及异基因骨髓移植的作用:EBMT 慢性恶性肿瘤工作组的观点。
Bone Marrow Transplant. 2022 Nov;57(11):1642-1648. doi: 10.1038/s41409-022-01774-8. Epub 2022 Aug 8.