肌肉减少症不会影响多发性骨髓瘤患者自体造血干细胞移植巩固治疗的结果。
Sarcopenia Does Not Impact the Outcome of Patients with Multiple Myeloma Consolidated with Autologous Hematopoietic Stem Cell Transplantation.
机构信息
Hematology and Stem Cell Transplantation Unit, Fondazione Policlinico Campus Bio Medico di Roma, Rome, Italy.
Operative Research Unit of Gastroenterology Fondazione Policlinico Campus Bio Medico di Roma, Rome, Italy.
出版信息
Chemotherapy. 2024;69(3):133-140. doi: 10.1159/000535692. Epub 2024 Feb 8.
INTRODUCTION
Sarcopenia has been associated with chronic diseases and cancer. The aim of this study was to evaluate sarcopenia in multiple myeloma patients undergoing autologous stem cell transplantation.
METHODS
In 68 eligible patients, measurement of skeletal muscle area (cm2) on computed tomography scans at the level of the L3 vertebra (L3 SMI) was performed.
RESULTS
37 (54%) patients were categorized as sarcopenic: 26 males with L3 SMI values <52.4 cm2/m2, and 11 women with L3 SMI values <38.9 cm2/m2. The majority of sarcopenic patients included were older than 60 years (69%, p = 0.0005), with BMI <25 (75%; p = 0.0000). A significant association was found between sarcopenia and Sorror score value >1 (p = 0.02).
CONCLUSIONS
The Kaplan-Meier curve showed a median OS of 73.5 months for non-sarcopenic patients versus 86.5 months for sarcopenic patients, suggesting that sarcopenia is not an independent prognostic factor in this cohort of patients. Further prospective studies are needed to confirm these data.
简介
肌肉减少症与慢性疾病和癌症有关。本研究旨在评估接受自体干细胞移植的多发性骨髓瘤患者的肌肉减少症情况。
方法
在 68 名符合条件的患者中，对 L3 椎骨（L3 SMI）水平的计算机断层扫描（CT）扫描进行骨骼肌面积（cm2）测量。
结果
37 名（54%）患者被归类为肌肉减少症患者：26 名男性的 L3 SMI 值＜52.4 cm2/m2，11 名女性的 L3 SMI 值＜38.9 cm2/m2。大多数肌肉减少症患者年龄大于 60 岁（69%，p=0.0005），BMI＜25（75%，p=0.0000）。肌肉减少症与 Sorror 评分值＞1 之间存在显著相关性（p=0.02）。
结论
Kaplan-Meier 曲线显示非肌肉减少症患者的中位总生存期为 73.5 个月，肌肉减少症患者的中位总生存期为 86.5 个月，表明肌肉减少症不是该患者队列的独立预后因素。需要进一步的前瞻性研究来证实这些数据。
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