Wang Lu, Wang Xiaoxia, Jiang Fujie, Cao Ying, Liu Shuling, Chen Huifang, Yang Jing, Zhang Xiaoyong, Yu Tao, Xu Hanshan, Lin Meng, Wu Yongzhong, Zhang Jiuquan
Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), Chongqing 400030, China.
School of Medicine, Chongqing University, Chongqing 400030, China.
Magn Reson Imaging. 2024 May;108:98-103. doi: 10.1016/j.mri.2024.02.005. Epub 2024 Feb 7.
OBJECTIVES: To investigate the feasibility of T1rho-weighted imaging in differentiating malignant from benign breast lesions and to explore the additional value of T1rho to conventional MRI. MATERIALS AND METHODS: We prospectively enrolled consecutive women with breast lesions who underwent preoperative T1rho-weighted imaging, diffusion-weighted imaging, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) between November 2021 and July 2023. The T1rho, apparent diffusion coefficient (ADC), and semi-quantitative parameters from DCE-MRI were obtained and compared between benign and malignant groups. The diagnostic performance was analyzed and compared using receiver operating characteristic (ROC) curves and the Delong Test. RESULTS: This study included 113 patients (74 malignant and 39 benign lesions). The mean T1rho value in the benign group (92.61 ± 22.10 ms) was significantly higher than that in the malignant group (72.18 ± 16.37 ms) (P < 0.001). The ADC value and time to peak (TTP) value in the malignant group (1.13 ± 0.45 and 269.06 ± 106.01, respectively) were lower than those in the benign group (1.57 ± 0.45 and 388.30 ± 81.13, respectively) (all P < 0.001). T1rho combined with ADC and TTP showed good diagnostic performance with an area under the curve (AUC) of 0.896, a sensitivity of 81.0%, and a specificity of 87.1%. The specificity and sensitivity of the combination of T1rho, ADC, and TTP were significantly higher than those of the combination of ADC and TTP (87.1% vs. 84.6%, P < 0.005; 81.0% vs. 77.0%, P < 0.001). CONCLUSION: T1rho-weighted imaging was a feasible MRI sequence for differentiating malignant from benign breast lesions. The combination of T1rho, ADC and TTP could achieve a favorable diagnostic performance with improved specificity and sensitivity, T1rho could serve as a supplementary approach to conventional MRI.
目的：探讨T1rho加权成像在鉴别乳腺良恶性病变中的可行性，并探索T1rho相对于传统磁共振成像（MRI）的附加价值。 材料与方法：我们前瞻性地纳入了2021年11月至2023年7月期间连续的患有乳腺病变并接受术前T1rho加权成像、扩散加权成像和动态对比增强磁共振成像（DCE-MRI）的女性患者。获取T1rho、表观扩散系数（ADC）以及DCE-MRI的半定量参数，并在良性和恶性组之间进行比较。使用受试者操作特征（ROC）曲线和德龙检验分析并比较诊断性能。 结果：本研究纳入了113例患者（74例恶性病变和39例良性病变）。良性组的平均T1rho值（92.61±22.10毫秒）显著高于恶性组（72.18±16.37毫秒）（P<0.001）。恶性组的ADC值和达峰时间（TTP）值（分别为1.13±0.45和269.06±106.01）低于良性组（分别为1.57±0.45和388.30±81.13）（所有P<0.001）。T1rho联合ADC和TTP显示出良好的诊断性能，曲线下面积（AUC）为0.896，敏感性为81.0%，特异性为87.1%。T1rho、ADC和TTP联合的特异性和敏感性显著高于ADC和TTP联合（87.1%对84.6%，P<0.005；81.0%对77.0%，P<0.001）。 结论：T1rho加权成像是鉴别乳腺良恶性病变的可行MRI序列。T1rho、ADC和TTP联合可实现良好的诊断性能，特异性和敏感性均有所提高，T1rho可作为传统MRI的补充方法。
Zhonghua Zhong Liu Za Zhi. 2021-8-23
Magn Reson Med Sci. 2010
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