Richard-Lenoble D, Kombila M, Nguembi-Mbina C, Gendrel D
Arch Fr Pediatr. 1985 Dec;42 Suppl 2:977-81.
Parasitic infections are endemic in children in Africa, making eradication an impossibility. Therapy is directed towards the individual manifesting an imbalance in the host-parasite relationship. Sanitation education is often disappointing, and until effective vaccines are developed, drug therapy remains the only worthwhile intervention. In order for a drug to be used on a mass campaign basis, financial considerations and side effects are of primary importance. Mefloquine has been shown to be a useful second line drug for chloroquine resistant strains of malaria in our Parasitology department. Benzimidazoles in a single dose are useful for intestinal nematode infections. New drugs are now available for schistosomiasis, filariasis, and protozoan infections.
寄生虫感染在非洲儿童中呈地方性流行,因此根除是不可能的。治疗针对的是表现出宿主 - 寄生虫关系失衡的个体。卫生教育往往令人失望,在开发出有效疫苗之前,药物治疗仍然是唯一值得的干预措施。为了在大规模运动中使用一种药物,财务考虑和副作用至关重要。在我们寄生虫学部门,甲氟喹已被证明是治疗耐氯喹疟原虫菌株的有用二线药物。单剂量的苯并咪唑对肠道线虫感染有效。现在有新药可用于治疗血吸虫病、丝虫病和原生动物感染。