The immunological consequences of allogeneic rat embryo transfer.

Blastocysts of the PVG and DA rat strains were transferred to pseudopregnant females of the opposite strain. Those embryos of which the biological and surrogate mothers were allogeneic with respect to each other exhibited a significantly impaired rate of survival. Lymphocytes from PVG rats born following the transfer of blastocysts to DA surrogates invariably possessed anti-(PVG X DA)F1 hybrid graft-versus-host reactivity substantially in excess of that of cells from normal PVG rats.