大鼠淋巴细胞所表达的抗原决定簇与其参与移植物抗宿主反应之间的关系。

The relationship of the antigenic determinants expressed by rat lymphoid cells to their participation in graft-versus-host reactions.

作者信息

McCullagh P

出版信息

Aust J Exp Biol Med Sci. 1985 Dec;63 ( Pt 6):635-43. doi: 10.1038/icb.1985.66.

DOI:10.1038/icb.1985.66

Abstract

The relationship between the graft-versus-host reactivity of lymphocytes from F2 hybrid and backcross rats and their susceptibility to inter-parental strain alloantisera has been investigated. Apart from associations between the immunological responsiveness of individual rats and the extent of alloantiserum susceptibility of their lymphocytes, selective reactivity of groups of lymphocytes that were separable from the general population by means of their alloantiserum susceptibility was observed. Those host lymphocytes which expressed a preponderance of DA-derived determinants were preferentially implicated in graft-versus-host reactions elicited by PVG lymphocytes in (PVG X DA)F2 hybrid rats. The anti-(PVG X DA)F1 hybrid reactivity of some (PVG X F1) backcross rats was selectively concentrated in that fraction of the lymphocyte population which expressed the highest levels of PVG-derived determinants. It is proposed that heterogeneously expressed MHS determinants may have a role in regulating selective participation by subpopulations of lymphocytes in allogeneic reactions.

摘要

对F2杂种大鼠和回交大鼠淋巴细胞的移植物抗宿主反应性与其对亲本品系同种异体抗血清易感性之间的关系进行了研究。除了个别大鼠的免疫反应性与其淋巴细胞对同种异体抗血清的敏感程度之间的关联外，还观察到通过其对同种异体抗血清的易感性可从总体中分离出来的淋巴细胞群体的选择性反应性。在（PVG×DA）F2杂种大鼠中，那些表达大量DA衍生决定簇的宿主淋巴细胞优先参与PVG淋巴细胞引发的移植物抗宿主反应。一些（PVG×F1）回交大鼠的抗（PVG×DA）F1杂种反应性选择性地集中在淋巴细胞群体中表达最高水平PVG衍生决定簇的部分。有人提出，异质性表达的主要组织相容性系统（MHS）决定簇可能在调节淋巴细胞亚群对同种异体反应的选择性参与中起作用。