Jiang Jiangang, Shu Hongyang, Wang Dao Wen, Hui Rutai, Li Chenze, Ran Xiao, Wang Hong, Zhang Jing, Nie Shaoping, Cui Guanglin, Xiang Dingcheng, Shao Qun, Xu Shengyong, Zhou Ning, Li Yuming, Gao Wei, Chen Yuguo, Bian Yuan, Wang Guoping, Xia Liming, Wang Yan, Zhao Chunxia, Zhang Zhiren, Zhao Yuhua, Wang Jianan, Chen Shaoliang, Jiang Hong, Chen Jing, Du Xianjin, Chen Mao, Sun Yinxian, Li Sheng, Ding Hu, Ma Xueping, Zeng Hesong, Lin Li, Zhou Shenghua, Ma Likun, Tao Ling, Chen Juan, Zhou Yiwu, Guo Xiaomei
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Sci China Life Sci. 2024 May;67(5):913-939. doi: 10.1007/s11427-023-2421-0. Epub 2024 Feb 7.
Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium. It is characterized by acute onset, rapid progress and high risk of death. Its pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory storm. According to China's practical experience, the adoption of the "life support-based comprehensive treatment regimen" (with mechanical circulation support and immunomodulation therapy as the core) can significantly improve the survival rate and long-term prognosis. Special emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.
暴发性心肌炎是一种急性弥漫性心肌炎症性疾病。其特点为起病急、进展快、死亡风险高。其发病机制涉及固有免疫系统的过度免疫激活及炎症风暴的形成。根据我国实际经验,采用“以生命支持为依托的综合救治方案”(以机械循环支持和免疫调节治疗为核心)可显著提高生存率及改善远期预后。特别强调要做到极早期识别、极早期诊断、极早期预测和极早期治疗。