Liu Gaotian, Xue Bing, Guan Yafei, Luo Xianwu
Wuhan University School of Nursing, Wuhan, China.
Department of International Medical Services, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Front Aging Neurosci. 2024 Jan 25;15:1254523. doi: 10.3389/fnagi.2023.1254523. eCollection 2023.
To evaluate the effect of repetitive transcranial magnetic stimulation (rTMS) paired with cognitive training on cognitive function in Alzheimer's Disease (AD) patients.
PubMed, The Cochrane Library, Embase, CINAHL Complete (EBSCO), China National Knowledge Infrastructure (CNKI) and WanFang Database were searched. The risk of bias was appraised through the Cochrane collaboration tool. A meta-analysis was conducted, including an assessment of heterogeneity.
Ten studies comprising 408 participants were included. The addition of rTMS significantly improved overall cognition in patients compared with cognitive intervention alone ( < 0.05 for all tests). The treatment also had some continuity, with significant improvements in cognitive function within weeks after the treatment ended ( < 0.05 for all tests).
Repetitive transcranial magnetic stimulation combined with cognitive training (rTMS-CT) is a valuable technique for the cognitive rehabilitation of AD patients. It is beneficial to improve the cognitive ability of patients and restore their overall functional state. The results of the study may provide a basis for clinical providers to implement interventions that facilitate the design of more rigorous and high-quality interventions.
The number of studies and sample size in our study were small. We did not explore possible interactions between rTMS and medications and mood improvement after rTMS due to inadequate data.
This study was registered on PROSPERO with registration number CRD42023405615.
评估重复经颅磁刺激（rTMS）联合认知训练对阿尔茨海默病（AD）患者认知功能的影响。
检索了PubMed、Cochrane图书馆、Embase、CINAHL Complete（EBSCO）、中国知网（CNKI）和万方数据库。通过Cochrane协作工具评估偏倚风险。进行了荟萃分析，包括异质性评估。
纳入了10项研究，共408名参与者。与单纯认知干预相比，添加rTMS显著改善了患者的整体认知（所有测试P<0.05）。治疗也具有一定的持续性，在治疗结束后的数周内认知功能有显著改善（所有测试P<0.05）。
重复经颅磁刺激联合认知训练（rTMS-CT）是AD患者认知康复的一项有价值的技术。它有助于提高患者的认知能力，恢复其整体功能状态。该研究结果可为临床医生实施干预措施提供依据，有助于设计更严谨、高质量的干预措施。
本研究的研究数量和样本量较小。由于数据不足，我们未探讨rTMS与药物之间可能的相互作用以及rTMS后的情绪改善情况。
本研究在PROSPERO上注册，注册号为CRD4202340561
