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结构化住院脂质治疗方案在优化非他汀类降脂治疗中的作用:一项综述及单中心经验

The role of structured inpatient lipid protocols in optimizing non-statin lipid lowering therapy: a review and single-center experience.

作者信息

Gier Chad, Gilchrist Ian, Fordham Matthew, Riordan Luke, Milchan Ella, Patel Nidhi, Mojahedi Azad, Choudhury Sahana, Kits Tara, Cohen Regina, Doughtery Joseph, Reilly John P, Kalogeropoulos Andreas, Rahman Tahmid, Chen On

机构信息

Stony Brook Heart Institute, Stony Brook University Hospital, Stony Brook, NY, United States.

Stony Brook Renaissance School of Medicine, Stony Brook, NY, United States.

出版信息

Front Cardiovasc Med. 2024 Jan 25;11:1284562. doi: 10.3389/fcvm.2024.1284562. eCollection 2024.

DOI:10.3389/fcvm.2024.1284562
PMID:38333418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10851935/
Abstract

Dyslipidemia is a leading contributor to atherosclerotic cardiovascular disease (ASCVD). There has been a significant improvement in the treatment of dyslipidemia in the past 10 years with the development of new pharmacotherapies. The intent of this review is help enhance clinicians understanding of non-statin lipid lowering therapies in accordance with the 2022 American College of Cardiology Expert Consensus Clinical Decision Pathway on the Role of Non-statin Therapies for LDL-Cholesterol Lowering. We also present a single-center experience implementing a systematic inpatient protocol for lipid lowering therapy for secondary prevention of ASCVD.

摘要

血脂异常是动脉粥样硬化性心血管疾病(ASCVD)的主要促成因素。在过去10年中,随着新药物疗法的发展,血脂异常的治疗有了显著改善。本综述的目的是根据2022年美国心脏病学会关于非他汀类药物降低低密度脂蛋白胆固醇作用的专家共识临床决策路径,帮助临床医生更好地理解非他汀类降脂疗法。我们还介绍了在单中心实施系统性住院患者血脂降低治疗方案以进行ASCVD二级预防的经验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c740/10851935/deb4d9ee2a92/fcvm-11-1284562-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c740/10851935/42f95671bc1b/fcvm-11-1284562-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c740/10851935/deb4d9ee2a92/fcvm-11-1284562-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c740/10851935/42f95671bc1b/fcvm-11-1284562-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c740/10851935/deb4d9ee2a92/fcvm-11-1284562-g002.jpg

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本文引用的文献

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Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients.贝匹地酸在他汀类药物不耐受患者中的心血管结局。
N Engl J Med. 2023 Apr 13;388(15):1353-1364. doi: 10.1056/NEJMoa2215024. Epub 2023 Mar 4.
2
Long-Term Evolocumab in Patients With Established Atherosclerotic Cardiovascular Disease.在已确诊动脉粥样硬化性心血管疾病患者中使用长效依洛尤单抗的研究
Circulation. 2022 Oct 11;146(15):1109-1119. doi: 10.1161/CIRCULATIONAHA.122.061620. Epub 2022 Aug 29.
3
2022 ACC Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk: A Report of the American College of Cardiology Solution Set Oversight Committee.
Int J Mol Sci. 2024 May 27;25(11):5841. doi: 10.3390/ijms25115841.
2022年美国心脏病学会解决方案集监督委员会关于非他汀类疗法在降低低密度脂蛋白胆固醇以管理动脉粥样硬化性心血管疾病风险中的作用的专家共识决策路径报告。
J Am Coll Cardiol. 2022 Oct 4;80(14):1366-1418. doi: 10.1016/j.jacc.2022.07.006. Epub 2022 Aug 25.
4
Use of Lipid-Lowering Therapies Over 2 Years in GOULD, a Registry of Patients With Atherosclerotic Cardiovascular Disease in the US.在美国动脉粥样硬化性心血管疾病患者登记库GOULD中,降脂疗法两年以上的使用情况。
JAMA Cardiol. 2021 Sep 1;6(9):1060-1068. doi: 10.1001/jamacardio.2021.1810.
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Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis.家族性高胆固醇血症或动脉粥样硬化患者依洛尤单抗临床试验的汇总患者水平分析。
J Am Coll Cardiol. 2021 Mar 9;77(9):1182-1193. doi: 10.1016/j.jacc.2020.12.058.
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JAMA Netw Open. 2020 Nov 2;3(11):e2025505. doi: 10.1001/jamanetworkopen.2020.25505.
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JAMA Cardiol. 2020 Oct 1;5(10):1124-1135. doi: 10.1001/jamacardio.2020.2314.
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Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease: The CLEAR Wisdom Randomized Clinical Trial.贝匹地酸对比安慰剂联合最大耐受他汀类药物治疗对心血管疾病高危患者的低密度脂蛋白胆固醇的影响:CLEAR Wisdom 随机临床试验。
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2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.2019年欧洲心脏病学会/欧洲动脉粥样硬化学会血脂异常管理指南:通过血脂修饰降低心血管风险
Eur Heart J. 2020 Jan 1;41(1):111-188. doi: 10.1093/eurheartj/ehz455.
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Heart. 2019 Jul;105(13):975-981. doi: 10.1136/heartjnl-2018-314253. Epub 2019 Apr 15.