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泰国2型糖尿病患者以患者为中心的护理系统与常规服务系统的临床结局及经济评估

Clinical outcomes and economic evaluation of patient-centered care system versus routine-service system for patients with type 2 diabetes in Thailand.

作者信息

Prayoonhong Watanyoo, Sonsingh Wannakamol, Permsuwan Unchalee

机构信息

Pharmacy Department, Phimai Hospital, Nakhon Ratchasima, Thailand.

Graduate Student in Pharmacy Management, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.

出版信息

Heliyon. 2024 Jan 23;10(3):e25093. doi: 10.1016/j.heliyon.2024.e25093. eCollection 2024 Feb 15.

Abstract

INTRODUCTION

Patient-centered care in diabetes is another approach for outcome improvement, yet the supporting economic and clinical evidence remains limited in Thailand.

OBJECTIVES

This study compared health outcomes and cost-utility of implementing Patient-Centered Care Systems (PCCS) in a primary care setting vs. the Routine Service System (RSS) in a hospital setting.

METHODS

The economic evaluation was performed using a randomized controlled study design. The participants aged ≥18 were enrolled from Phimai City in Nakhon Ratchasima Province, Thailand from June 2022 to February 2023. Totally, 309 well-controlled patients with initial care in a hospital were referred to receive the PCCS at the primary care setting or remained receiving the RSS in the hospital. Outcomes of different approaches such as fasting blood sugar, Hemoglobin A1c (HbA1c), direct medical costs, direct nonmedical costs and utility were prospectively collected at months 0, 3 and 6. Fisher's exact test, -test or Wilcoxon signed-rank test were used to analyze data, whichever was appropriate. An incremental cost-effectiveness ratio was calculated, and various sensitivity analyses were performed.

RESULTS

The PCCS showed significantly reduced HbA1c (p < 0.001) and a greater number of patients with improved HbA1c (p < 0.001). The PCCS were a cost-saving strategy due to incurring lower total costs (60.15 vs. 73.42 USD) and gaining more quality-adjusted life-years (QALY)(0.340 vs. 0.330) compared with the RSS. With a ceiling ratio of 4,659 USD/QALY, the PCCS had a 94.6 % probability of being cost-effective.

CONCLUSION

This finding indicated that the PCCS in a primary care setting was a cost-saving strategy by lowering cost, providing a higher quality of life and improving glycemic control compared with the RSS in a hospital setting. However, generalizing the findings in a country as a whole, the economic evaluation of PCCS and RSS should be conducted among different levels of hospitals from all regions in Thailand.

摘要

引言

以患者为中心的糖尿病护理是改善治疗效果的另一种方法,但在泰国,支持该方法的经济和临床证据仍然有限。

目的

本研究比较了在初级保健环境中实施以患者为中心的护理系统(PCCS)与在医院环境中实施常规服务系统(RSS)的健康结果和成本效益。

方法

采用随机对照研究设计进行经济评估。2022年6月至2023年2月,从泰国呵叻府披迈市招募年龄≥18岁的参与者。共有309名在医院接受初始护理且病情得到良好控制的患者被转介到初级保健环境中接受PCCS,或留在医院接受RSS。在第0、3和6个月前瞻性收集不同方法的结果,如空腹血糖、糖化血红蛋白(HbA1c)、直接医疗成本、直接非医疗成本和效用。根据数据情况,使用Fisher精确检验、t检验或Wilcoxon符号秩检验进行分析。计算增量成本效益比,并进行各种敏感性分析。

结果

PCCS组的HbA1c显著降低(p < 0.001),且HbA1c改善的患者数量更多(p < 0.001)。与RSS相比,PCCS是一种成本节约策略,因为其总成本更低(60.15美元对73.42美元),且获得了更多的质量调整生命年(QALY)(0.340对0.330)。以4659美元/QALY的上限比率计算,PCCS具有成本效益的概率为94.6%。

结论

这一发现表明,与医院环境中的RSS相比,初级保健环境中的PCCS是一种成本节约策略,它降低了成本,提高了生活质量并改善了血糖控制。然而,如果要将这些结果推广到整个国家,应该在泰国所有地区的不同级别医院中对PCCS和RSS进行经济评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f961/10850510/201ecbbdcfec/gr1.jpg

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