Department of Biochemistry, United Institute of Medical Sciences, Rawatpur, Prayagraj, Uttar Pradesh, 211012, India.
Department of Paramedical Sciences, Mahayogi, Gorakhnath University, Gorakhpur, Uttar Pradesh, 273007, India.
Endocr Metab Immune Disord Drug Targets. 2024;24(10):1161-1168. doi: 10.2174/0118715303257835231117062928.
The prevalence of diabetes is rapidly increasing in India, even among young adult individuals. Rare adiponectin gene () variants may be predominantly present in Indians and decrease the circulatory levels of APN (Adiponectin). Studies reported that gene variants were associated with type 2 diabetes mellitus (T2DM) and its complications in the Indian population.
To review the association of specific gene variants with T2DM and its associated complications.
MATERIALS & METHODS: A search of Pubmed, Chinhal, Medline, Scopus, Web of Science databases, and Google Scholar search engine was performed to retrieve articles by using the following keywords; " and T2DM", " and India," " gene variants and T2DM", " gene variants and T2DM and India", "SNPs of gene and T2DM", "SNPs of gene and India," SNPs of gene and T2DM and India". Eligibility criteria for the inclusion of articles: Original, Case-Control Study, and Full-Text articles were published in the English language till the end of April 2023.
A total of 540 articles were retrieved. Out of this, only 18 articles were found suitable to include in this systematic narrative review. The most studied gene variants were found to be +10211T/G (rs17846866), +45T/G (rs2241766), and +276G/T (rs1501299) in different Indian populations.
It was reviewed that gene variants +10211T/G (rs17846866), +45T/G (rs2241766), and +276G/T (rs1501299) were predominantly present in the Indian population, and decreasing the circulatory levels of APN and significantly associated with T2DM and its complications.<.
糖尿病在印度的发病率正在迅速上升，甚至在年轻成年人中也是如此。罕见的脂联素基因（）变体可能主要存在于印度人群中，并降低 APN（脂联素）的循环水平。研究报告称，基因变体与印度人群中的 2 型糖尿病（T2DM）及其并发症有关。
综述特定基因变体与 T2DM 及其相关并发症的关系。
通过 Pubmed、Chinhal、Medline、Scopus、Web of Science 数据库和 Google Scholar 搜索引擎进行检索，使用以下关键词检索文章：“和 T2DM”、“和印度”、“基因变体和 T2DM”、“基因变体和 T2DM 和印度”、“基因的 SNPs 和 T2DM”、“基因的 SNPs 和印度”、“基因的 SNPs 和 T2DM 和印度”。纳入文章的标准：原始的、病例对照研究和全文文章，发表在英语语言，直到 2023 年 4 月底。
共检索到 540 篇文章。其中，只有 18 篇文章适合纳入本系统叙述性综述。在不同的印度人群中，研究最多的基因变体被发现是+10211T/G(rs17846866)、+45T/G(rs2241766)和+276G/T(rs1501299)。
综述发现，基因变体+10211T/G(rs17846866)、+45T/G(rs2241766)和+276G/T(rs1501299)在印度人群中主要存在，降低 APN 的循环水平，并与 T2DM 及其并发症显著相关。
