Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, P.R. China.
Central Laboratory of Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410005, P.R. China.
Oncol Rep. 2024 Mar;51(3). doi: 10.3892/or.2024.8712. Epub 2024 Feb 9.
Cholangiocarcinoma (CCA) is a disease characterized by insidious clinical manifestations and challenging to diagnose. Patients are usually diagnosed at an advanced stage and miss the opportunity for radical surgery. Therefore, effective palliative therapy is the main treatment approach for unresectable CCA. Current common palliative treatments include biliary drainage, chemotherapy, radiotherapy, targeted therapy and immunotherapy. However, these treatments only offer limited improvement in quality of life and survival. Photodynamic therapy (PDT) is a novel local treatment method that is considered a safe tumor ablation method for numerous cancers. It has shown good efficacy in various studies of CCA and is expected to become an important treatment for CCA. In the present study, the mechanisms of PDT in the treatment of CCA were systematically explored and the progress in the research of photosensitizers was discussed. The current study focused on the various PDT protocols and their therapeutic effects in CCA, with the objective of providing a new horizon for future research and clinical applications of PDT in the treatment of CCA.
胆管癌（CCA）是一种临床表现隐匿且难以诊断的疾病。患者通常在晚期被诊断出来，错过了根治性手术的机会。因此，有效的姑息治疗是不可切除 CCA 的主要治疗方法。目前常见的姑息治疗方法包括胆道引流、化疗、放疗、靶向治疗和免疫治疗。然而，这些治疗方法仅能有限地提高生活质量和延长生存时间。光动力疗法（PDT）是一种新的局部治疗方法，被认为是多种癌症的安全肿瘤消融方法。它在 CCA 的各种研究中显示出良好的疗效，有望成为 CCA 的一种重要治疗方法。在本研究中，系统地探讨了 PDT 治疗 CCA 的机制，并讨论了光敏剂的研究进展。本研究重点介绍了各种 PDT 方案及其在 CCA 中的治疗效果，旨在为 PDT 在 CCA 治疗中的未来研究和临床应用提供新的思路。
