Department of Clinical Sciences, Tufts University, Cummings School of Veterinary Medicine, Foster Hospital for Small Animals, North Grafton, Massachusetts, USA.
J Vet Intern Med. 2024 Mar-Apr;38(2):1051-1059. doi: 10.1111/jvim.16998. Epub 2024 Feb 9.
Outcomes of dogs with acute kidney injury secondary to leptospirosis (AKI-L) treated using renal replacement therapies (RRT) are poorly characterized.
HYPOTHESIS/OBJECTIVES: Describe survival to discharge, short (≤30 days) and long-term (≥6 months) outcomes of AKI-L dogs receiving RRT and determine if there is a significant difference in maximum blood urea nitrogen (maxBUN), maximum creatinine (maxCr), maximum bilirubin (maxBili) and the number of body systems affected between survivors and non-survivors.
Twenty-two client-owned dogs with AKI-L receiving RRT.
Retrospective medical record review of dogs with AKI-L that received RRT between 2018 and 2021.
Sixteen of 22 (73%) dogs survived to discharge. Of the survivors, 13 (81%) were alive >30 days from discharge and 12 (75%) were alive at 6 months from discharge. Factors significantly higher in non-survivors included number of body systems affected (survivors: 1 (19%), 2 (50%), 3 (25%) and 4 (6%) vs non-survivors: 3 (33.3%), and 4 (66.7%); P = .01) and median maxBili (survivors: 1.9 mg/dL; range, 0.1-41.6 vs non-survivors: 21.0 mg/dL; range, 12.3-38.9; P = .02). There was no significant difference in median maxBUN (survivors: 153.0 mg/dL; range, 67-257 vs non-survivors: 185.5 mg/dL; range, 102-218; P = .44) and median maxCr (survivors: 9.8 mg/dL; range, 6.2-15.9 vs non-survivors: 9.8 mg/dL; range, 8.4-13.5; P = .69) between survivors and non-survivors.
Regardless of azotemia severity, dogs with AKI-L receiving RRT have a good survival rate to discharge. The number of body systems affected and hyperbilirubinemia might be associated with worse outcomes.
接受肾脏替代疗法（RRT）治疗的钩端螺旋体病继发急性肾损伤（AKI-L）犬的预后特征描述不佳。
假设/目的：描述接受 RRT 的 AKI-L 犬的存活出院情况、短期（≤30 天）和长期（≥6 个月）预后，并确定存活者和非存活者之间最大血尿素氮（maxBUN）、最大肌酐（maxCr）、最大胆红素（maxBili）和受影响的身体系统数量是否存在显著差异。
2018 年至 2021 年间接受 RRT 的 22 只 AKI-L 患犬。
对接受 RRT 的 AKI-L 犬进行回顾性病历审查。
22 只犬中有 16 只（73%）存活出院。在幸存者中，13 只（81%）在出院后 30 天以上仍存活，12 只（75%）在出院后 6 个月仍存活。非幸存者中显著更高的因素包括受影响的身体系统数量（幸存者：1（19%）、2（50%）、3（25%）和 4（6%）与非幸存者：3（33.3%）和 4（66.7%）；P = .01）和中位数 maxBili（幸存者：1.9mg/dL；范围，0.1-41.6 与非幸存者：21.0mg/dL；范围，12.3-38.9；P = .02）。幸存者和非幸存者之间的中位 maxBUN（幸存者：153.0mg/dL；范围，67-257 与非幸存者：185.5mg/dL；范围，102-218；P = .44）和中位数 maxCr（幸存者：9.8mg/dL；范围，6.2-15.9 与非幸存者：9.8mg/dL；范围，8.4-13.5；P = .69）无显著差异。
无论氮血症严重程度如何，接受 RRT 的 AKI-L 犬的出院存活率都很高。受影响的身体系统数量和高胆红素血症可能与预后不良相关。
