Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
J Vet Pharmacol Ther. 2024 Jul;47(4):280-287. doi: 10.1111/jvp.13430. Epub 2024 Feb 9.
Additional immunomodulatory treatment is needed for the management of immune-mediated disease in horses. Mycophenolate mofetil (MMF) is an immunomodulatory agent used in human and veterinary medicine for the prevention of graft rejection and the management of autoimmune diseases. Few studies exist investigating the pharmacokinetics of MMF in horses. The aim of this study was to evaluate the pharmacokinetics of a single dose of MMF in healthy horses in the fed vs. fasted state. Six healthy Standardbred mares were administered MMF 10 mg/kg by a nasogastric (NG) tube in a fed and fasted state. A six-day washout period was performed between the two doses. No statistically significant differences in mycophenolic acid (MPA) concentrations were seen at any time point apart from 8 h, when plasma metabolite concentrations were significantly higher in the fasted state compared to the fed state (p = .038). Evidence of enterohepatic recirculation was seen only in the fasted state; this did not yield clinical differences in horses administered a single-dose administration but may be significant in horses receiving long-term MMF treatment.
对于马的免疫介导性疾病的治疗，需要额外的免疫调节治疗。霉酚酸酯（MMF）是一种免疫调节剂，在人类和兽医医学中用于预防移植物排斥和治疗自身免疫性疾病。研究 MMF 在马中的药代动力学的研究很少。本研究的目的是评估在进食和禁食状态下，健康马单次给予 MMF 的药代动力学。6 匹健康的标准母马通过鼻胃管在进食和禁食状态下给予 MMF 10mg/kg。在两次给药之间进行了六天的清洗期。除了 8 小时外，在任何时间点，MPA 浓度均无统计学差异，在禁食状态下，与进食状态相比，血浆代谢物浓度显著更高（p=0.038）。仅在禁食状态下观察到肠肝再循环的证据；这在给予单次剂量给药的马中没有产生临床差异，但在接受 MMF 长期治疗的马中可能具有重要意义。
