Li Chaonan, Mo Yalan, Jiao Luying, Liu Yiping, Li Xiaogang
College of Plant Protection, Hunan Agricultural University, Changsha 410128, China.
Hunnan Cotton Science Institute, Changde 415000, China.
Nanomaterials (Basel). 2024 Jan 23;14(3):250. doi: 10.3390/nano14030250.
Mesoporous silica nanoparticles (MSNs) can be used as carrier materials for the controlled release of pesticides while reducing their negative environmental impact. In this study, we screened an active ingredient, p-cymene (PC), with an excellent inhibitory effect on rice bacterial blight. Subsequently, the PC was successfully loaded onto MSNs via physisorption (PC@MSNs). PC@MSNs, characterized by a regular spherical shape, smooth surface, and an MSN average size of 262.9 nm, achieved an 8.6% drug loading capacity. The release kinetics of the PC from the PC@MSNs demonstrated a sustained release (288 h) pattern influenced by drug diffusion. The efficacy of the PC@MSNs against pv. paralleled those of PC. Acute toxicity assays revealed that the PC@MSNs were less toxic to aquatic life (LC = 257.867 mg/L) and that the formulation showed no adverse effects on rice seedling growth. In summary, these results suggest that PC@MSNs can broaden PC's scope of application in managing rice diseases.
介孔二氧化硅纳米颗粒（MSNs）可作为农药控释的载体材料，同时减少其对环境的负面影响。在本研究中，我们筛选出了一种对水稻白叶枯病具有优异抑制作用的活性成分对伞花烃（PC）。随后，通过物理吸附将PC成功负载到MSNs上（PC@MSNs）。PC@MSNs具有规则的球形形状、光滑的表面，MSN平均尺寸为262.9 nm，载药量达到8.6%。PC从PC@MSNs中的释放动力学表现出受药物扩散影响的持续释放（288小时）模式。PC@MSNs对水稻白叶枯病菌的防治效果与PC相当。急性毒性试验表明，PC@MSNs对水生生物的毒性较小（LC = 257.867 mg/L），并且该制剂对水稻幼苗生长没有不良影响。总之，这些结果表明PC@MSNs可以拓宽PC在水稻病害防治中的应用范围。
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