Ningxia Medical University, Ningxia, China.
Department of Respiratory Medicine, Ningxia Hospital of Integrated Traditional Chinese and Western Medicine, Ningxia, China.
Medicine (Baltimore). 2024 Feb 9;103(6):e37033. doi: 10.1097/MD.0000000000037033.
Primary tracheal acinic cell carcinoma (ACC) is an exceptionally rare malignancy, posing challenges in understanding its clinical behavior and optimal management. Surgical resection has traditionally been the primary treatment modality, but we present a compelling case of tracheal ACC managed with endotracheal intervention, challenging conventional approaches.
A 53-year-old woman presented with shortness of breath, cough, and hemoptysis. Enhanced computed tomography revealed an obstructive tracheal lesion, leading to her referral for further assessment.
Microscopic evaluation, immunohistochemistry, and clinical assessments confirmed primary tracheal ACC, an exceedingly rare condition with limited clinical insights.
We utilized rigid bronchoscopy to perform endotracheal intervention, successfully resecting the tumor and restoring tracheal patency. Postoperatively, the patient received no radiotherapy or chemotherapy.
The patient achieved complete recovery, with 24-month follow-up examinations indicating no recurrence or metastatic disease. Only minimal scar tissue remained at the resection site.
This case demonstrates the potential of endotracheal intervention as a curative approach for primary tracheal ACC, minimizing invasiveness and preserving tracheal function. Collaborative research efforts and extensive case reporting are crucial for advancing our understanding of this rare malignancy and optimizing treatment strategies for improved patient outcomes.
原发性气管腺样囊性癌（ACC）是一种极其罕见的恶性肿瘤，其临床行为和最佳治疗方案的理解存在挑战。传统上，手术切除是主要的治疗方式，但我们提出了一个极具说服力的气管 ACC 病例，采用了气管内介入治疗，挑战了传统方法。
一名 53 岁女性因呼吸困难、咳嗽和咯血就诊。增强 CT 显示气管阻塞性病变，因此转至我院进一步评估。
通过显微镜评估、免疫组织化学和临床评估，确诊为原发性气管 ACC，这是一种罕见的疾病，临床数据有限。
我们使用硬式支气管镜进行气管内介入治疗，成功切除肿瘤并恢复气管通畅。术后，患者未接受放疗或化疗。
患者完全康复，24 个月随访检查未发现复发或转移疾病。切除部位仅残留少量疤痕组织。
该病例表明，气管内介入治疗作为原发性气管 ACC 的一种根治方法具有潜力，可最大限度减少侵袭性并保留气管功能。协作研究和广泛的病例报告对于深入了解这种罕见的恶性肿瘤以及优化治疗策略以改善患者预后至关重要。
