Lietman P S
Clin Perinatol. 1979 Mar;6(1):151-62.
In a therapeutic tragedy perhaps even more widespread than the thalidomide disaster, untold lives were lost between 1949 and 1958 through the administration of inappropriate doses of chloramphenicol to newborn infants. Sensitive assays of blood levels of chloramphenicol now available make it possible to employ this useful antibiotic avoiding its toxic effects. The author reviews accumulated knowledge about chloramphenicol in the newborn infant.
在一场或许比沙利度胺灾难更为普遍的治疗悲剧中,1949年至1958年间,由于给新生儿不恰当地使用氯霉素,导致了无数生命的消逝。如今可用的氯霉素血药浓度灵敏检测方法,使得在使用这种有用抗生素时能够避免其毒性作用。作者回顾了关于新生儿使用氯霉素的累积知识。