Department of Human Nutrition and Hospitality Management, University of Alabama, Tuscaloosa, AL 35487, USA.
Nutrients. 2024 Jan 31;16(3):422. doi: 10.3390/nu16030422.
Newborns' eyes and brains are prone to oxidative stress. Lutein has antioxidant properties and is the main component of macular pigment essential for protecting the retina, but has low bioavailability, thereby limiting its potential as a nutritional supplement. Oil-in-water emulsions have been used as lutein delivery systems. In particular, octenylsuccinated (OS) starch is a biopolymer-derived emulsifier safe to use in infant foods, while exhibiting superior emulsifying capacity. This study determined the effects of an OS starch-stabilized lutein emulsion on lutein bioavailability in Sprague-Dawley neonatal rats. In an acute study, 10-day-old pups received a single oral dose of free lutein or lutein emulsion, with subsequent blood sampling over 24 h to analyze pharmacokinetics. The lutein emulsion group had a 2.12- and 1.91-fold higher maximum serum lutein concentration and area under the curve, respectively, compared to the free lutein group. In two daily dosing studies, oral lutein was given from postnatal day 5 to 18. Blood and tissue lutein concentrations were measured. The results indicated that the daily intake of lutein emulsion led to a higher lutein concentration in circulation and key tissues compared to free lutein. The OS starch-stabilized emulsion could be an effective and safe lutein delivery system for newborns.
新生儿的眼睛和大脑容易受到氧化应激的影响。叶黄素具有抗氧化特性，是保护视网膜所必需的黄斑色素的主要成分，但生物利用度低，从而限制了其作为营养补充剂的潜力。油包水乳剂已被用作叶黄素的递送系统。特别是辛烯基琥珀酸（OS）淀粉是一种源自生物聚合物的乳化剂，可安全用于婴儿食品，同时具有卓越的乳化能力。本研究旨在确定 OS 淀粉稳定的叶黄素乳剂对 Sprague-Dawley 新生大鼠中叶黄素生物利用度的影响。在一项急性研究中，10 天大的幼鼠接受单次口服游离叶黄素或叶黄素乳剂，随后在 24 小时内采集血液样本以分析药代动力学。与游离叶黄素组相比，叶黄素乳剂组的血清叶黄素最大浓度和曲线下面积分别高出 2.12 倍和 1.91 倍。在两项每日给药研究中，从出生后第 5 天至 18 天给予口服叶黄素。测量血液和组织中叶黄素的浓度。结果表明，与游离叶黄素相比，每日摄入叶黄素乳剂可使循环和关键组织中的叶黄素浓度更高。OS 淀粉稳定的乳剂可能是新生儿有效且安全的叶黄素递送系统。
