Fagret D, Bontemps L, Apparu M, Keriel C, Mathieu J P, Pernin C, Vidal M, Comet M, Cuchet P
Int J Nucl Med Biol. 1985;12(5):363-7.
The methyl-branched fatty acids, if radioiodine labelled in alpha position, are potentially adapted to a selective study of FA myocardial uptake. To determine the position and the number of methyl radicals that are necessary to obtain a maximal uptake and a minimal degradation, we measured time-activity evolution of isolated and perfused rat hearts after an injection of iodinated fatty acids which are mono- or dimethylated in alpha or beta position. Except for dimethyl fatty acid, the uptake is similar for all fatty acids studied to that of the straight chain analogue; beta mono- or dimethyl fatty acids seem best adapted to a study of the uptake because alpha monomethyl fatty acids undergo a metabolic degradation and alpha mono- and dimethyl fatty acids induce ventricular fibrillations.
如果甲基支链脂肪酸在α位用放射性碘标记，那么它们有可能适用于脂肪酸心肌摄取的选择性研究。为了确定获得最大摄取量和最小降解所需的甲基基团的位置和数量，我们在注射了在α或β位单甲基化或二甲基化的碘化脂肪酸后，测量了离体灌注大鼠心脏的时间-活性变化。除了二甲基脂肪酸外，所有研究的脂肪酸的摄取与直链类似物相似；β位单甲基或二甲基脂肪酸似乎最适合用于摄取研究，因为α位单甲基脂肪酸会发生代谢降解，而α位单甲基和二甲基脂肪酸会诱发心室颤动。
