College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Key Laboratory of Functional Inorganic Materials Chemistry (Ministry of Education), School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, China.
Colloids Surf B Biointerfaces. 2024 Mar;235:113792. doi: 10.1016/j.colsurfb.2024.113792. Epub 2024 Feb 7.
In this study, an amphiphilic polymer FA-CS-DBA-CHO with aggregation-induced emission (AIE) feature was prepared by introducing 4-(diphenylamino)benzaldehyde derivative (DBA-CHO), imine bond and folic acid (FA) to the molecular structure of chitosan (CS). The amphiphilicity drove the polymer to self-assemble into micelles, and paclitaxel (PTX) could be solubilized in the hydrophobic core. Due to the excellent AIE effect, FA-CS-DBA-CHO exhibited strong cellular imaging capability. The pH-sensitive imine bond in the polymer allowed for accurate drug release in acidic environment. Both in vitro and in vivo studies demonstrated that the PTX-loaded FA-CS-DBA-CHO micelles could significantly inhibit the growth of tumor cells but without any notable toxicity. This micellar system was excellent carrier for bioimaging and chemotherapeutic drug delivery.
在这项研究中，通过在壳聚糖（CS）的分子结构中引入 4-（二苯氨基）苯甲醛衍生物（DBA-CHO）、亚胺键和叶酸（FA），制备了具有聚集诱导发射（AIE）特性的两亲性聚合物 FA-CS-DBA-CHO。两亲性促使聚合物自组装成胶束，紫杉醇（PTX）可以溶解在疏水性核中。由于具有优异的 AIE 效应，FA-CS-DBA-CHO 表现出强大的细胞成像能力。聚合物中 pH 敏感的亚胺键允许在酸性环境中进行精确的药物释放。体外和体内研究均表明，载紫杉醇的 FA-CS-DBA-CHO 胶束能够显著抑制肿瘤细胞的生长，但没有明显的毒性。该胶束系统是生物成像和化疗药物递送的优秀载体。
