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具有 AIE 特性的氧化还原敏感胶束用于生物成像和高效抗癌药物递送。

AIE-Featured Redox-Sensitive Micelles for Bioimaging and Efficient Anticancer Drug Delivery.

机构信息

Department of Pharmaceutical Engineering, School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, China.

College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, China.

出版信息

Int J Mol Sci. 2022 Sep 16;23(18):10801. doi: 10.3390/ijms231810801.

DOI:10.3390/ijms231810801
PMID:36142713
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9505945/
Abstract

In the present study, an amphiphilic polymer was prepared by conjugating methoxy poly(ethylene glycol) (mPEG) with tetraphenylethene (TPE) via disulfide bonds (Bi(mPEG-S-S)-TPE). The polymer could self-assemble into micelles and solubilize hydrophobic anticancer drugs such as paclitaxel (PTX) in the core. Combining the effect of TPE, mPEG, and disulfide bonds, the Bi(mPEG-S-S)-TPE micelles exhibited excellent AIE feature, reduced protein adsorption, and redox-sensitive drug release behavior. An in vitro intracellular uptake study demonstrated the great imaging ability and efficient internalization of Bi(mPEG-S-S)-TPE micelles. The excellent anticancer effect and low systemic toxicity were further evidenced by the in vivo anticancer experiment. The Bi(mPEG-S-S)-TPE micelles were promising drug carriers for chemotherapy and bioimaging.

摘要

在本研究中，通过二硫键（Bi(mPEG-S-S)-TPE）将甲氧基聚乙二醇（mPEG）与四苯乙烯（TPE）偶联制备了一种两亲聚合物。该聚合物可以自组装成胶束，并将疏水性抗癌药物如紫杉醇（PTX）溶解在核心中。结合 TPE、mPEG 和二硫键的作用，Bi(mPEG-S-S)-TPE 胶束表现出优异的聚集诱导发光（AIE）特性、减少蛋白质吸附和氧化还原敏感的药物释放行为。体外细胞内摄取研究表明，Bi(mPEG-S-S)-TPE 胶束具有出色的成像能力和高效的内化能力。体内抗癌实验进一步证明了其优异的抗癌效果和低系统毒性。Bi(mPEG-S-S)-TPE 胶束有望成为用于化疗和生物成像的药物载体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/79d872c5f621/ijms-23-10801-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/d8273e63ca68/ijms-23-10801-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/0ef0114bca15/ijms-23-10801-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/6b13996ac377/ijms-23-10801-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/4700efe491a3/ijms-23-10801-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/58ad4f084c43/ijms-23-10801-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/79d872c5f621/ijms-23-10801-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/d8273e63ca68/ijms-23-10801-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/0ef0114bca15/ijms-23-10801-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/6b13996ac377/ijms-23-10801-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/4700efe491a3/ijms-23-10801-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/58ad4f084c43/ijms-23-10801-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/9505945/79d872c5f621/ijms-23-10801-g005.jpg

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本文引用的文献

[1]
Correction: Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy.

RSC Adv. 2020-4-2

[2]
A novel biocompatible zwitterionic polyurethane with AIE effect for cell imaging in living cells.

RSC Adv. 2018-2-12

[3]
New and Emerging Targeted Therapies for Advanced Breast Cancer.

Int J Mol Sci. 2022-2-18

[4]
Emerging nanomedicines of paclitaxel for cancer treatment.

J Control Release. 2022-2

[5]
Fabrication of hyaluronic acid-based micelles with glutathione-responsiveness for targeted anticancer drug delivery.

J Colloid Interface Sci. 2022-1-15

[6]
Preparation of camptothecin micelles self-assembled from disodium glycyrrhizin and tannic acid with enhanced antitumor activity.

Eur J Pharm Biopharm. 2021-7

[7]
Redox-sensitive polymeric micelles with aggregation-induced emission for bioimaging and delivery of anticancer drugs.

J Nanobiotechnology. 2021-1-7

[8]
Thermostable polymeric nanomicelles of iridium(iii) complexes with aggregation-induced phosphorescence emission characteristics and their recyclable double-strand DNA monitoring.

J Mater Chem B. 2017-1-7

[9]
Biocompatible reduction-responsive polypeptide micelles as nanocarriers for enhanced chemotherapy efficacy in vitro.

J Mater Chem B. 2013-1-7

[10]
Dual tumor-targeted multifunctional magnetic hyaluronic acid micelles for enhanced MR imaging and combined photothermal-chemotherapy.

Colloids Surf B Biointerfaces. 2018-2-5

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