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蛋白质结合对稳态方程的影响。

Effect of protein binding on steady-state equations.

作者信息

Wagner J G

出版信息

J Pharmacokinet Biopharm. 1985 Oct;13(5):559-60. doi: 10.1007/BF01059338.

DOI:10.1007/BF01059338
PMID:3834070
Abstract

Previously published steady-state equations assumed elimination of total drug. The equations have been derived to cover the case where only free (unbound) drug is eliminated. The equation for oral administration is the same in both cases. The equation for intravenous administration has the same form, but the interpretation of Km is different.

摘要

先前发表的稳态方程假设消除的是总药物。这些方程已推导出来以涵盖仅消除游离（未结合）药物的情况。两种情况下口服给药的方程是相同的。静脉给药的方程形式相同，但对Km的解释不同。

相似文献

1
Effect of protein binding on steady-state equations.蛋白质结合对稳态方程的影响。
J Pharmacokinet Biopharm. 1985 Oct;13(5):559-60. doi: 10.1007/BF01059338.
2
Dose equations without protein-binding parameters.不含蛋白质结合参数的剂量方程。
Int J Clin Pharmacol Biopharm. 1978 Oct;16(10):463-6.
3
Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data.线性药代动力学方程允许根据已拟合数据的多指数方程的系数和指数直接计算许多所需的药代动力学参数。
J Pharmacokinet Biopharm. 1976 Oct;4(5):443-67. doi: 10.1007/BF01062831.
4
Model independent derivation of general equations for the "first-pass" effect and extra-hepatic drug elimination.“首过”效应和肝外药物消除通用方程的模型无关推导。
Eur J Clin Pharmacol. 1977;11(1):57-64. doi: 10.1007/BF00561789.
5
A nonlinear physiologic pharmacokinetic model: I. Steady-state.一种非线性生理药代动力学模型：I. 稳态
J Pharmacokinet Biopharm. 1985 Feb;13(1):73-92. doi: 10.1007/BF01073657.
6
A dispersion model of hepatic elimination: 2. Steady-state considerations--influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity.肝脏消除的弥散模型：2. 稳态考量——肝血流量、血液内结合以及肝细胞酶活性的影响
J Pharmacokinet Biopharm. 1986 Jun;14(3):261-88. doi: 10.1007/BF01106707.
7
A general equation for the ratio of the areas below the blood or plasma concentration time-curves following intravenous and oral drug administration and its application to inter-subject variations in drug elimination.静脉注射和口服给药后血药浓度或血浆浓度-时间曲线下面积之比的通用方程及其在药物消除个体间差异中的应用。
Br J Clin Pharmacol. 1975 Jun;2(3):239-50. doi: 10.1111/j.1365-2125.1975.tb01582.x.
8
Michaelis-Menten elimination kinetics: areas under curves, steady-state concentrations, and clearances for compartment models with different types of input.米氏消除动力学：不同输入类型的房室模型的曲线下面积、稳态浓度和清除率
Biopharm Drug Dispos. 1985 Apr-Jun;6(2):177-200. doi: 10.1002/bdd.2510060209.
9
Determination of volume of distribution at steady state with complete consideration of the kinetics of protein and tissue binding in linear pharmacokinetics.在线性药代动力学中，充分考虑蛋白质和组织结合动力学来测定稳态分布容积。
J Pharm Sci. 2004 Feb;93(2):364-74. doi: 10.1002/jps.10539.
10
The influence of drug kinetics in blood on the calculation of oral bioavailability in linear pharmacokinetics: the traditional equation may considerably overestimate the true value.线性药代动力学中血液药物动力学对口服生物利用度计算的影响：传统公式可能会显著高估真实值。
J Pharm Sci. 2006 Apr;95(4):834-48. doi: 10.1002/jps.20570.

本文引用的文献

1
Pharmacokinetic concepts - drug binding, apparent volume of distribution and clearance.药代动力学概念——药物结合、表观分布容积和清除率。
Eur J Clin Pharmacol. 1981;20(4):299-305. doi: 10.1007/BF00618781.
2
Letter: Effect of plasma protein binding on elimination of warfarin.信函：血浆蛋白结合对华法林消除的影响。
J Pharm Sci. 1974 May;63(5):805-6. doi: 10.1002/jps.2600630539.
3
A nonlinear physiologic pharmacokinetic model: I. Steady-state.一种非线性生理药代动力学模型：I. 稳态
J Pharmacokinet Biopharm. 1985 Feb;13(1):73-92. doi: 10.1007/BF01073657.